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Articles by Sunday Nkereuwem Etukudoh
Total Records ( 1 ) for Sunday Nkereuwem Etukudoh
  Paulinus Mfon Udoudoh , Daniel Ejim Uti , Emmanuel E. Edet , Sunday Nkereuwem Etukudoh , Blessing Godwin Ukwak , Uket Nta Obeten and Grace Ufedo Umoru
  Background and Objective: Persistent hyperglycaemia in diabetes mellitus (DM) could result to compromised hepatic function. Telfairia occidentalis (TEL) and Gongronema latifolium (GON) have both demonstrated glucose lowering potentials in previous investigations due to a rich mix of bioactive compounds in the plants. This study investigated the synergistic antidiabetic and hepatoprotective potentials of TEL and GON in diabetic rats. Materials and Methods: Six groups of animals were studied; normal control (NC), diabetic control (DC), metformin control (MET), TEL and GON groups, single and combine (n = 7). NC and DC received placebo treatments, other treatment groups were given 500 mg kg1 b.wt. doses of the extracts and MET for 21 days. The rats were sacrificed, blood and liver tissues collected for hepatic enzymes, haematological and histo-pathological evaluation. Results: Transferases (aspartate-AST and alanine-ALT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) increased in DC rats compared to NC (p<0.05). Treatment significantly decreased (p<0.05) the enzyme concentrations in TEL/GON treatment commensurate to standard MET. Haematological indices, white blood cells count (WBC) and its differentials lymphocytes (LYM) and monocytes (MON) were significantly increased (p<0.05) in DC compared to NC. Red blood cells (RBC) and platelets concentrations which decreased in DC were significantly increased (p<0.05) in all treatments and compared significantly to MET. Histo-pathological evaluation of the liver showed significant regeneration across all treatments with more pronounced effect in TEL/GON group. Conclusion: These findings reaffirmed the hypoglycaemic potentials of TEL and GON, suggesting these plants in synergism may potentiate a better hepatoprotective and increased antidiabetic activity.
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