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Articles by Sunday Blessing Oladele
Total Records ( 2 ) for Sunday Blessing Oladele
  Sunday Blessing Oladele , Ishiaku Enoch , Sa`idu Lawal and O.J. Ibu
  Experiments were performed to determine whether Japanese quails (Coturnix coturnix japonica) are susceptible to Newcastle disease virus (NDV) Kudu 113 strain. In the experimental trials, a total 119, six weeks old Japanese quails were administered varying doses of the virus, ranging from 0.1 ml to 0.3 ml intramuscularly (im) and per os (po). The uninfected control quails were not administered the virus and were reared separately. Depression, weakness, incoordination, anorexia, ruffled feathers and paralysis of legs and wings were noted in some of the infected quails. At necropsy, some of the infected quails also had haemorrhagic enteritis and congested lungs, liver, heart and spleen and muscles of breast, thighs and legs. There was a rise in haemagglutination inhibition (HI) antibody titre in all the infected quails, following administration of NDV Kudu 113 strain either im or po. The highest mean HI antibody titre of log2 10.56± 0.29 was obtained on day seven post infection (pi) in the group that was administered 0.3 ml of the virus im. Similarly, the highest mean HI antibody titre of log2 9.89±0.48 was obtained on day seven pi in quails that were administered 0.3 ml of the virus po. On the other hand, the control quails were negative to HI antibody test. This study demonstrated that Japanese quails are susceptible to NDV Kudu 113 strain.
  Sunday Blessing Oladele , King Akpofure Nelson Esievo , Paul Abdu and Andrew Jonathan Nok
  This study was carried out to determine the effects of cations on neuraminidase during NDV infections in poultry. A total of two hundred samples from dialyzed neuraminidase of NDV Kudu 113 strain were used for the experiment. Fifty samples each were used on four divalent cations, namely calcium (Ca2+), magnesium (Mg2+), mercury (Hg2+) and copper (Cu2+) ions. Neuraminidase activity of NDV Kudu 113 strain was determined in vitro in the presence of these cations, tested as their chloride form by periodate thiobarbituric acid assay method. Neuraminidase activity was also determined in the control samples that were without cations. Out of the four divalent cations examined, Hg2+ induced the highest neuraminidase activity of 75% at the concentration of 0.24M. Magnesium and Ca2+ ions also increased the activity of neuraminidase of NDV Kudu 113 strain in vitro. On the other hand, Cu2+ significantly inhibited the activity of this enzyme by 69.23% at the concentration of 0.47M. It was concluded that Ca2+, Mg2+ and Hg2+ induced increase in the activity of neuraminidase of NDV Kudu 113 strain, while Cu2+ inhibited its activity in vitro. Further studies should be carried out on the roles of these cations in Newcastle disease (ND) and the possible use of Cu2+ in the future as inhibitor of the activity of neuraminidase of NDV in vivo, so as to reduce the menance of ND in poultry.
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