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Articles by Sunarno
Total Records ( 2 ) for Sunarno
  Kasiyati , Muhammad Anwar Djaelani and Sunarno
  Background and Objective: Moringa oleifera is one of the local food ingredients with adequate nutrient content to act as an antioxidant, hypocholesterolemia and cardiac stimulant. This research was designed to study the effect of supplementation of moringa leaf powder, on reproductive performance and ovarian morphometry of Pengging ducks. Materials and Methods: The study used a complete randomized design, with a total of eighty female Pengging ducks, 24 weeks old divided into five treatment groups and four replicates of each. The first group (control) was fed basal diet, without the supplement of moringa leaf powder, while the second to the fifth group was fed a basal diet with 2.5, 5, 7.5 and 10% Moringa leaf supplementation. Results: Age of sexual maturity was 2-3 days faster in the duck fed diet supplemented with 2.5-10% Moringa leaf powder. Concentrations of serum glucose, cholesterol and LDL were lower (p<0.05) in the group fed with moringa leaf supplement, although serum HDL and protein concentrations increased (p<0.05). MDA level of the liver ducks were significantly influenced (p<0.05) by moringa leaf supplement, as the diameter of F1 and F2 follicles, increased (p<0.05) in the groups fed diet supplemented with moringa leaf powder. Conclusion: The moringa leaf powder supplementation of 2.5-10%, improved the reproductive profile of the Pengging ducks which was supported by an increased in diameter of F1 and F2 follicles, without an increase in the serum cholesterol and MDA of the liver and ovary concentrations. Hence, moringa leaf powder was significant as a hepatoprotector and oviprotector, in sexually mature Pengging ducks.
  Sunarno , Wasmen Manalu , Nastiti Kusumorini and Dewi Ratih Agungpriyono
  Physiological aging and aging due to oxidative stress decrease alanine-glutamine dipeptide concentrations in plasma and hippocampus. These conditions impact the decreased availability of glutamine in intracellular and glutathione levels in the hippocampus. Decrease in hippocampal glutathione level will be followed by decreased function of hippocampal neuron. One way to improve the function of the hippocampus is to increase the availability of glutamic acid in hippocampal neuronal cells. This study was designed to obtain the concentration profile of alanine-glutamine dipeptide in plasma and hippocampus and the repair function in the aging hippocampus is known from structural repairs to the mitochondria of neurons. The experimental rats were assigned into a completely randomized design with 2 x 2 x 2 factorial arrangement and three replications. The first factor was the age of the experimental rats, consisted of two levels i.e., 12 and 24 months. The second factor was oxidative stress consisted of two levels, i.e., without or with oxidative stress. The third factor was the concentration of alanine-glutamine dipeptide administration consisted of 2 concentrations, i.e., 0 and 7%. Administration of alanine-glutamine dipeptide 7% can improve function in the aging hippocampus, both in physiological aging or aging due to oxidative stress in younger or aged rats, in normal or oxidative stress rats. This research concluded that the alanine-glutamine dipeptide 7% gave the best results in increased alanine-glutamine dipeptide plasma and hippocampus, glutathione levels, the repair response of mitochondrial structure that mediates the repair function in the aging hippocampus.
 
 
 
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