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Articles by Sukrasno
Total Records ( 3 ) for Sukrasno
  Gunawan Pamudji Widodo , Elin Yulinah Sukandar , Sukrasno and I. Ketut Adnyana
  The aim of study was to isolate, characterize and elucidate of the antifungal compounds from acetone fraction of Ageratum leaves and to determine the antifungal activity of the isolated compounds. A coumarin compound has been isolated from acetone fraction of Ageratum leaves (Ageratum conyzoides L.) and chemical structure has been elucidated based on UV, IR, NMR and mass spectra. This compound showed an antifungal activity against the plant pathogenic fungi, Aspergillus niger. A. niger is a fungus and one of the most common species of the genus Aspergillus. It causes black mold on certain fruits and vegetables such as grape, onion and peanuts and is a common contaminant of food. The coumarin was tested for its antifungal activity against A. niger by disk diffusion method. The MIC values of coumarin was 62.5 μg mL-1.
  Lia Amalia , Kusnandar Anggadiredja , Sukrasno , Irda Fidrianny and Rini Inggriani
  The wild cosmos (Cosmos caudatus Kunth, Asteraceae) is one of the vegetables mostly consumed by rural people of Central and East Java Provinces of Indonesia and those of the Malay Peninsula. Yet, it has not been widely used medicinally. The leaf has distinctive taste as well as odor and contains high level of flavonoid, especially flavonol and flavon glycosides which have potent antioxidant activity. In this study, in an attempt to explore the antihypertensive effect, wild cosmos leaf aqueous extract was tested in rats treated with adrenaline and sodium chloride. The frequency of heart rate and amplitude of stroke volume were measured using the non-invasive tail cuff method. The extract at doses of 500 and 1000 mg kg-1 showed similar potency to that of 9 mg kg-1 atenonol, in lowering both parameters, induced by adrenaline. However, after sodium chloride, the extract only suppressed the amplitude and this effect was comparable to that of 0.45 mg kg-1 hydrochlorothiazide and 13.5 mg kg-1 captopril. Besides cardiac effects, the extract also demonstrated diuretic activity which was comparable to that of 1.8 mg kg-1 furosemide. Taken together, results of present study suggest that wild cosmos leaf extract have antihypertensive effect which may be related, at least in part, to the decreased cardiac output and induction of diuresis. The results may further indicate that consumption of wild cosmos leaf in diet is beneficial for hypertensive patients.
  Sukrasno , Kartika , Irda Fidrianny , Elfahmi and Khairul Anam
  Curcuma xanthorrhiza is one the most important of Indonesian crude drug. Its pharmacological activities are usually associated with curcuminoid and the essential oil content. This study was aimed at studying the influence of the crude drug preparation on the content and the composition of volatile oil Curcuma rhizome. The bulky rhizomes were stored at room temperatures and their volatile oil contents measured. The composition of the oil was analyzed by GC-MS. The rhizomes were sliced, dried, comminuted and their oil content measured. Storage of bulky rhizome at room temperature continuously decreased the yield of volatile oil from bulky fresh rhizome. Storage did not change the number and the identity of the oil component: However, it altered their composition. Germacron, xanthorrhizol and α-curcumene increased while dipi-α-cedren decreased during storage. Upon slicing, drying under the sun, drying in an air oven, grinding and storage of the dried Curcuma rhizome, most of the volatile oil was still retained in the crude drug. Storage of bulky Curcuma rhizome continuously decreased its volatile oil content and the lost of oil reach 57% after 12 weeks. It is suggested that to assure the highest level of volatile oil content in the preparation of Curcuma crude drug, the rhizome should be immediately sliced and dried after harvest.
 
 
 
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