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Articles by Subramanian Balakrishnan
Total Records ( 5 ) for Subramanian Balakrishnan
  Namasivayam Senthil , Shanmugam Manoharan , Subramanian Balakrishnan , Cinnamanoor Rajmani Ramachandran and Radhakrishnan Muralinaidu
  Aim of the present study was to find out the chemopreventive efficacy of Piper longum, a plant having diverse medicinal properties, in 7,12-dimethyl benz (a) anthracene (DMBA) induced oral carcinogenesis. The mechanistic pathway for its chemopreventive potential was analysed by measuring lipid peroxidation and antioxidants status in DMBA induced oral cancer. DMBA painting in hamster buccal pouch three times per week for 14 weeks resulted in well developed, well differentiated squamous cell carcinoma. Elevated lipid peroxidation and decline in antioxidants were noticed in tumor bearing hamsters as compared to control animals. Oral administration of ethanolic extract of Piper longum dried fruits (PLEFet) on alternate days to DMBA painting significantly prevented the tumor incidence, volume and burden and restored the status of lipid peroxidation and antioxidants in DMBA painted hamsters. Our results indicate that the dried fruits of P. longum has suppressing effects on cell proliferation, which is probably due to its antilipid peroxidative and antioxidative potential during DMBA induced oral carcinogenesis.
  Shanmugam Manoharan , Simon Silvan , Krishnamoorthi Vasudevan and Subramanian Balakrishnan
  Piper longum (Piperaceae family) is used in Indian traditional medicine as a remedy for various disorders including diabetes mellitus. The aim of the present study was to investigate the antihyperglycemic and antilipidperoxidative effects of ethanolic extract of Piper longum dried fruits (PLEFet) in alloxan induced diabetic rats. Diabetes mellitus was induced in overnight fasted (12 h) Wistar rats by single intraperitoneal injection of freshly prepared solution of alloxan monohydrate (150 mg kg-1 bw) in physiological saline. The blood glucose level, carbohydrate metabolizing enzymes and the status of lipid peroxidation and antioxidants were assayed using specific colorimetric methods. Oral administration of PLEFet has shown significant antihyperglycemic, antilipidperoxidative and antioxidant effects in diabetic rats. PLEFet also corrected the metabolic alterations observed by the activities of several carbohydrate metabolizing enzymes (hexokinase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, fructose 1.6-bisphosphatase and glycogen phosphorylase) in alloxan induced diabetic rats. The antihyperglycemic effect of PLEFet is comparable to that of the standard reference drug, glibenclamide. Present results indicate that PLEFet has potent antihyperglycemic and antilipidperoxidative effects in alloxan induced diabetic rats. PLEFet can therefore be used as an alternative remedy for diabetes and oxidative stress associated diabetic complications.
  Krishnamoorthi Vasudevan , Divianathan Sophia , Subramanian Balakrishnan and Shanmugam Manoharan
  Different parts of the Ficus racemosa plant products are employed in the Indian traditional medicine for the treatment of several disorders including diabetes mellitus. Our aim was to investigate the antihyperglycemic and antilipidperoxidative effects of aqueous and ethanolic extracts of Ficus racemosa bark (FrABet and FrEBet) in alloxan induced diabetic rats. Oral administration of FrABet and FrEBet at a dose of 400 and 300 mg kg-1 bw, respectively showed potent antihyperglycemic and antilipidperoxidative effects in alloxan induced diabetic rats. The extracts also improved the antioxidants defense system in alloxan induced diabetic rats. The FrEBet showed better effect than glibenclamide whereas the effect of FrABet was much comparable to that of glibenclamide (reference drug). Our results indicate that FrABet and FrEBet have prominent antidiabetic and antilipidperoxidative effects in experimental diabetes and can therefore be used as an alternative remedy for the treatment of diabetes mellitus and its complications.
  Gopi Lilly Renju , Shanmugam Manoharan , Subramanian Balakrishnan and Namasivayam Senthil
  The present study has investigated the chemopreventive and antilipidperoxidative effects of the ethanolic extract of Clerodendron inerme leaves (CiELet) in DMBA induced skin carcinogenesis in Swiss albino mice. The skin squamous cell carcinoma was induced in the shaved back of mice, by painting with DMBA (25 μg 0.1 mL-1 acetone) twice weekly for 8 weeks. We have observed 100% tumor formation in the fifteenth week of experimental period. Elevated lipid peroxidation and decline in enzymatic and non-enzymatic antioxidants status was observed in tumor bearing mice. Oral administration of CiELet (300 mg kg-1 bw) for 25 weeks significantly prevented the tumor incidence, volume and burden of the tumor. The CiELet also showed potent antilipidperoxidative effect as well as enhanced the antioxidant defense mechanisms in DMBA painted mice. The present study thus demonstrated the chemopreventive and antilipidperoxidative efficacy of CiELet in DMBA induced mouse skin carcinogenesis.
  Shanmugam Manoharan , Ganapathy Sindhu , Madhavan Ramados Nirmal , Venkatesan Vetrichelvi and Subramanian Balakrishnan
  Investigation of expression pattern of molecular markers in oral epithelial tissues would help to assess the cell differentiation and proliferation as well as early diagnosis of precancerous and cancerous lesions of the oral cavity. Aim of the present study was to investigate the protective effect of berberine on expression pattern of apoptotic, cell proliferative, inflammatory and angiogenic markers during 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Immunohistochemical staining [p53, Bcl-2, Bax, Proliferating Cell Nuclear Antigen (PCNA) and Vascular Endothelial Growth Factor (VEGF)], Enzyme Linked Immuno Sorbent Assay (ELISA) [c-fos, COX-2, caspase-3 and -9] and Real-Time PCR [Cyclin D1 and NFκB] were utilized to assess the expression pattern of molecular markers in DMBA induced hamster buccal pouch carcinogenesis. Over expression of mutant p53, PCNA, Bcl-2 and VEGF were noticed in hamsters treated with DMBA alone. Decreased expression of Bax protein was noticed in hamsters treated with DMBA alone. Increased expression of C-fos, COX-2, NFκB and Cyclin D1 and decreased activities of caspase-3 and -9 were also noticed in hamsters treated with DMBA alone. Oral administration of berberine at a dose of 75 mg kg-1 b.w. brought back the expression of above mentioned molecular markers to near normal pattern in hamsters treated with DMBA. The present results thus suggest that berberine has potent anti-inflammatory, anti-angiogenic, anti-cell proliferative and apoptosis inducing properties in DMBA induced oral carcinogenesis.
 
 
 
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