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Articles by Subhash L. Bodhankar
Total Records ( 6 ) for Subhash L. Bodhankar
  Subhash L. Bodhankar and Sachin L. Badole
  No Description
  Arvindkumar E. Ghule , Suresh S. Jadhav and Subhash L. Bodhankar
  Background: Renal Artery Occlusion (RAO) induced hypertension is a major health problem associated with structural and functional modifications of the renal and cardiac vasculature. The present study was designed to investigate the antihypertensive activity of ethanolic extract of seeds of Linum usitatissimum (EELU) in RAO induced hypertensive rats. Materials and methods: Male Wistar rats (180-200 g) were divided in four groups Sham, RAO, EELU 200 mg kg-1 and EELU 400 mg kg-1. Treatment group were pretreated with EELU (200 and 400 mg kg-1) for 4 weeks. After that on last day of the experiment, left renal artery was occluded with renal bulldog clamp for 4 h. The right carotid artery was cannulated, renal clamp was removed and immediately subjected to hemodynamic recording and assessment of left ventricular function. Results: RAO group significantly increased hemodynamic parameters at 15, 30 and 45 min of clamp removal. EELU (400 mg kg-1) treated group significantly decreased hemodynamic parameters at 15 min after clamp removal which remained for 60 min. EELU (400 mg kg-1) treated group showed significant improvement in left ventricular function at 15, 30 and 45 min of clamp removal. The flow cytometric analysis showed significant decrease in Reactive Oxygen Species (ROS) production by renal cells in EELU (400 mg kg-1) treated group as compared with RAO group which indicated antioxidant activity of EELU. Conclusion: It is concluded from the present investigation that the antihypertensive activity of EELU may be resulted through the action on rennin angiotensin system and inhibition of ROS.
  Sandipan Sarkar , Antara Sengupta , Answesha Mukhrjee , Anamika Guru , Anagha Patil , Amit D. Kandhare and Subhash L. Bodhankar
  Background: Peptic ulcer disease is a result of an imbalance between aggressive and defensive factors. Morin, a bioflavonoid exhibits many biological activities such as antioxidant and anti-inflammatory properties. Objective: The present study was conducted to unravel the therapeutic potential of morin in acetic acid-induced gastric ulcer. Materials and Methods: Gastric ulcer was induced in male Wistar rats (180-220 g) by applying glacial acetic acid (10 M, 100 μL) to serosa of the stomach. Morin (10, 30 and 100 mg kg-1, p.o.) was administered for 15 days after the induction of ulcer. After end of treatment gastric specimens were collected for biochemical and histological evaluation. Results: There was a significant (p<0.01 and p<0.05) reduction in the ulcer area and ulcer index by morin (30 and 100 mg kg-1) treatment. It also significantly (p<0.01 and p<0.05) decreased the level of malondialdehyde (MDA) and increased levels of superoxide dismutase (SOD) as well as reduced glutathione (GSH). Histological aberration induced by acetic acid also reduced by morin administration. Conclusion: The present findings elucidate the antiulcer potential of morin in the acetic acid induced gastric ulcer by virtue of its antioxidant property.
  Amit D. Kandhare , Anagha Patil , Anamika Guru , Anwesha Mukhrjee , Sandipan Sarkar , Antara Sengupta , Hari Mohan Parmar , Amol P. Muthal , Pralhad Wangikar and Subhash L. Bodhankar
  Background: Inflammatory Bowel Disease (IBD) is a chronic disease of unknown etiology, which is characterized by chronic and spontaneously relapsing inflammation. Objective: To evaluate the effect of ferulic acid on acetic acid-induced IBD in rats. Materials and Methods: Ulcerative colitis was induced in male Wistar rats (180-220 g) by intrarectal instillation of 2 mL of 4% (v/v) acetic acid solution. Rats were treated orally with either ferulic acid (10, 20 and 40 mg kg–1, p.o.), prednisolone (2 mg kg–1) or distilled water (10 mg kg–1). Various biochemical, molecular and histological parameters were evaluated. Results: Intrarectal administration of 4% acetic acid resulted in significant alteration (p<0.05) in ulcer area, serum alkaline phosphatase, serum lactate dehydrogenase and colonic superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) content. Administration of ferulic acid (20 and 40 mg kg–1) significantly (p<0.05) ameliorated these acetic acid-induced alterations. There was a significant (p<0.05) down-regulation in colonic HO-1 mRNA expression, which was significantly up-regulated (p<0.05) by ferulic acid (20 and 40 mg kg–1). The decreased colonic Nfr2 level after acetic acid instillation was increased by ferulic acid (20 and 40 mg kg–1) treatment, which was revealed by immunohistochemical analysis. Histological aberration induced after acetic acid instillation was inhibited by ferulic acid. Conclusion: The findings of the present investigation showed that ferulic acid has an anti-inflammatory and anti-oxidant potential to inhibit acetic acid-induced colitis via upregulation in the HO-1 and Nrf-2 expressions.
  Amit D. Kandhare , Mithun V.K. Patil and Subhash L. Bodhankar
  Background: Inflammatory Bowel Disease (IBD) is a chronic inflammatory, an idiopathic disorder of intestine with unknown etiology. Alstonia scholaris Linn., R.Br. (family Apocynaceae) shown to possesses potent antioxidant and anti-inflammatory activity. Objective: To evaluate the effect of an alkaloidal fraction of leaves of Alstonia scholaris (AFEAS) against acetic acid induced IBD in laboratory rats. Materials and Methods: Colitis was induced in male Wistar rats (180-220 g) by intrarectal administration of acetic acid (2 mL, 4% (v/v)). Rats were either treated orally with AFEAS (20, 40 and 80 mg kg–1) or distilled water (10 mg kg–1) or prednisolone (2 mg kg–1). Various biochemical, molecular and histological parameter were assessed. Results: Intrarectal administration of 4% acetic acid resulted in significant modulation (p<0.05) of serum alkaline phosphatase, lactate dehydrogenase, SOD, GSH, MDA and MPO content along with colonic NO, XO level and protein carbonyl content in the colonic tissue as well as in blood. The AFEAS (40 and 80 mg kg–1) administration significantly (p<0.05) ameliorated these acetic acid induced alteration in serum and colonic biochemical parameters. The decreased level of leptin and increased the level of pro-inflammatory cytokines (TNF-α and IL-1β) after acetic acid administration were significantly inhibited by AFEAS (40 and 80 mg kg–1) treatment. The AFEAS treatment reduced histological insult induced in the colon after intrarectal instillation of acetic acid. Conclusion: Treatment of AFEAS ameliorates acetic acid induced colitis by virtue of its anti-inflammatory and anti-oxidant potential via inhibition of production oxido-inflammatory mediator and pro-inflammatory cytokines.
  Sameer H. Sawant and Subhash L. Bodhankar
  Background: Recently the antihyperlipidemic, cardioprotective and in vitro antioxidant activity of Flax Lignan Concentrate (FLC) obtained from Linum usitatissimum Linn. (Linaceae) has been reported. The present study was aimed to assess the antihypertensive effect of FLC in L-NAME-induced hypertensive rats. Materials and Methods: Wistar rats (200-240 g) were given L-NAME (40 mg kg–1 b.wt. day–1, p.o.) in drinking water for 4 weeks to induce hypertension. Rats were randomly divided into six groups: Control, L-NAME control, captopril (30 mg kg–1, p.o.) and FLC (200, 400 and 800 mg kg–1, p.o.). The FLC and standard drug captopril (30 mg kg–1) were also administered daily for 4 weeks. Result: The FLC (400 and 800 mg kg–1) significantly (p<0.01 and p<0.001) and dose-dependently decreased the elevated Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Blood Pressure (MABP). It also normalized the altered left ventricular End Diastolic Pressure (EDP), dP/dt max. and dP/dt min. It also prevented the increase in heart weight and a decrease in heart rate and body weight. Undesirable changes, such as increased malondialdehyde (MDA) level and decreased the concentration of enzymatic antioxidants superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione (GSH) in the tissues (heart and aorta) were rectified after the administration of FLC (400 and 800 mg kg–1). Oral administration of FLC (400 and 800 mg kg–1) decreased Angiotensin Converting Enzyme (ACE) and also prevented the decrease in nitrite and nitrate concentration and cyclic guanosine monophosphate (cGMP) levels in plasma and tissues (heart and aorta). Conclusion: These finding suggested that the antihypertensive property of FLC in L-NAME hypertensive rats may be because of increased bioavailability of NO, ACE inhibition and antioxidant nature.
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