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Articles by Subhash C. Mandal
Total Records ( 6 ) for Subhash C. Mandal
  Saikat Dewanjee , Anup Maiti , Ranabir Sahu , Tarun Kumar Dua and Subhash C. Mandal
  Hydroalcoholic extract of Schima wallichii Choisy. (Ternstroemiaceae) bark (HESW) was investigated for its anti-inflammatory, antinociceptive, and antipyretic activities. The anti-inflammatory effects of the HESW were assayed by using carrageenan and dextran (acute model) induced paw edema and cotton pellet granuloma assay (chronic model) in experimental rats. Oral administration of HESW at the doses of 150 and 300mg/kg caused dose-dependent inhibition of carrageenan and dextran induced inflammation. HESW at the doses of 150 and 300mg/kg caused significant dose-dependent reduction of the granuloma tissue formation in experimental rats. The extract at the oral doses of 50 and 100mg/kg body weight exhibited significant central and peripheral analgesic activity in acetic acid induced writhing test and hot-plate test respectively in experimental mice. Treatment with HESW at the oral doses of 150 and 300mg/kg body weight significantly reduced the yeast-provoked elevated body temperature in experimental rats in a dose-dependent manner.
  Saikat Dewanjee , Ranabir Sahu , Vivekananda Mandal , Anup Maiti and Subhash C. Mandal
  Chronic diabetes complications are mainly associated with augmented oxidative stress. Thus the present study evaluated the hypoglycemic, as well the antioxidant effect, of the methanol extract of Diospyros peregrina Gurke. (Ebenaceae) fruits on experimental diabetic rats. Oral administration of methanol extract at 150 and 300mg/kg body weight per day to diabetic rats was found to have profound hypoglycemic activity in term of reduction of fasting blood glucose level. The diabetic rats showed lower activities of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) content in hepatic and renal tissues as compared with normal rats. The activities of SOD, CAT, and GSH were found to be increased in extract-treated diabetic rats in selected tissues. The increased levels of lipid peroxidation (thiobarbituric acid reactive substances and hydroperoxides) in diabetic rats were also found to be reverted back to near-normal status in extract-treated groups. It was found that the extract is more effective at the dose of 300mg/kg body weight and this effect is almost comparable to that of standard glibenclamide.
  Nilanjan Ghosh , Rituparna Ghosh , Vivekananda Mandal and Subhash C. Mandal
  Context: Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centuries as the toxicity factor appears to be on the lower side. Objective: Several phytochemials have been identified which have significant hepatoprotective activity with minimal systemic adverse effects which could limit their long term use. The scenario calls for extensive investigations which can lead to development of lead molecules for hepatoprotective molecules of future. This review deals with the biological activity, mode of action and toxicity and forthcoming application of some of these leads. Methods: These generally have strong antioxidative potential and cause induction of antioxidant enzymes like superoxide dismutase, reduced glutathione and catalase. Additional mechanisms of hepatoprotection include stimulation of heme oxygenase-1 activity, inhibition of nitric oxide production, hepatocyte apoptosis and nuclear factor-κB activation. Results and conclusion: Out of the several leads obtained from plant sources as potential hepatoprotective agents, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have been established as potent hepatoprotective agents. The hepatoprotective potential of several herbal medicines has been clinically evaluated. Significant efficacy has been seen with silymarin, glycyrrhizin and Liv-52 in treatment of hepatitis, alcoholic liver disease and liver cirrhosis.
  Velmani Gopal , Vivekananda Mandal and Subhash C. Mandal
  Objective: Wattakaka volubilis is widely used in Indian traditional medicine to treat pain, cough, fever, dyspepsia and diabetes. This study explores the antidiabetic potential of Petroleum Ether Cold Maceration Extract (PEME) of Wattakaka volubilis in alloxan induced diabetes in rats. Materials and Methods: The Petroleum Ether Cold Macerated Extract (PEME) of W. volubilis was evaluated to quantify lupeol by HPTLC method. Male Wistar rats were divided into five groups (with six rats each) and fed at libitum: the control (0.9% saline), alloxan treated rats with or without supplementary PEME of W. volubilis and metformin (50,100 and 250 mg kg-1 b.wt.) for three weeks. The blood-glucose, α-amylase, Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) and bilirubin levels were measured on 7, 14 and 21 day of PEME treatment on alloxan treated rats. Results: Histopathological changes in the pancreas, kidney and liver were examined with hematoxylin-eosin staining. The PEME had 382.82 μg of lupeol, treatment of PEME in experimental rats by oral injections for 21 days showed reductions in the levels of serum biochemical markers. Histopathology results showed that PEME administration suppressed the abnormal cellular degenerations in alloxan treated rats. Conclusion: These results suggest that PEME has a protective effect over alloxan-induced diabetes.
  Velmani Gopal , Vivekananda Mandal and Subhash C. Mandal
  Diabetic mellitus is characterized by multiple metabolic disorders of carbohydrate metabolism, resulted chronic hyperglycemia with the insulin deficiency and resistance in the pancreatic β-cells. A new treatment paradigm for patient with diabetes to achieve and maintain normal glycemic control is necessary. Oral monotherapy for diabetes is initiated when diet and exercise do not control hyperglycemia. Insulin is the last therapeutic option used when multiple oral combination treatment fails. In recent years, there has been a marked rise in the prescribing of insulin analogues. Clinical trials have demonstrated equal or superior efficacy and safety outcomes of these analogues when compared with human insulin, particularly lower incidence of hypoglycemic events.
  S.A. Nirmal , L.L. Sonawane , G.S. Asane , S.C. Pal and Subhash C. Mandal
  Background: Ulcerative Colitis (UC) is a subcategory of inflammatory bowel disease and it refers to a large group of disorders that affect the gastrointestinal system. It has many serious effects and large population from European country is suffering from this disease so attempts to find new medicines from natural sources are needed. Objectives: The roots of Tephrosia purpurea (Leguminosae) are used in the treatment of ulcer and colic pain traditionally hence present work was undertaken to validate it scientifically and to identify the phytoconstituent responsible for this activity. Material and Methods: Various extracts of root were screened for Ulcerative Colitis (UC) using the method acetic acid induced ulcerative colitis in mice. Aqueous extract was found most active and hence fractionated by column chromatography. Various fractions obtained were screened for UC activity and fraction IV was found most active hence purified and subjected to spectroscopic analysis yielding a glycoside. Results: Results showed that fraction IV is found to contain a glycoside after spectroscopic study. This glycoside reduced level of myeloperoxidase and malondialdehyde in colon significantly. This glycoside showed significant protective effect in macroscopical study and histopathology observations of the colon. Conclusion: It can be concluded that the glycoside, 1, 4a, 7, 7a-tetrahydro-7-hydroxy-7-(hydroxymethyl)-1-(tetrahydro-3’,4’,5’-trihydroxy-6’-(hydroxymethyl)-2H-pyran-2’-yl oxy) cyclopenta (c) pyran-4-carboxylic acid might be responsible for the treatment of ulcerative colitis.
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