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Articles by Soodabeh Saeidnia
Total Records ( 9 ) for Soodabeh Saeidnia
  Amin Mokhlesi , Soodabeh Saeidnia , Ahmad Reza Gohari , Ahmad Reza Shahverdi , Ali Nasrolahi , Farzaneh Farahani , Reza Khoshnood and Nasrin Es`haghi
  Sea cucumbers are potentially presented as the marine sources of antimicrobial and cytotoxic compounds. In this study, we focused on the sea cucumber, Holothuria leucospilota which has not been evaluated until now for antibacterial, antifungal and toxicity of its main organs. Ethyl acetate, methanol and water-methanol extracts were prepared from cuvierian organ, coelomic fluid and body wall of H. leucospilota collected from Persian Gulf. Extracts were evaluated for their antibacterial and antifungal activities against Aspergillus niger, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The activity was determined using the disc diffusion test. Cytotoxic activities of the extracts were assessed by Artemia salina larvae. Results showed that methanol extract of cuvierian organ (Minimum inhibitory concentration (MIC/disc) <1 mg against A. niger) and water-methanol extract of coelomic fluid (MIC/disc = 1 mg against C. albicans) showed significant antifungal activities but no inhibitory effect of the extracts against bacteria was observed. MIC for water-methanol extract of coelomic fluid was 3 mg against both C. albicans and A. niger. Significant inhibitory effect was observed in cytotoxic assays which was highest in body wall methanol extract (LC50 = 0.4 μg mL-1).
  Soodabeh Saeidnia and Mohammad Abdollahi
  Not Available.
  Soodabeh Saeidnia , Azadeh Manayi and Mohammad Abdollahi
  Not Available.
  Soodabeh Saeidnia and Mohammad Abdollahi
  Cancer occurs when alterations of genetic material create an abnormal function leading to unregulated proliferation of cells in the body. Cancer remains as one of the most predominant illnesses causing death, where each year more than 10 million people are identified worldwide. Due to restrictions and side effects observed from various chemotherapeutic anti-cancer drugs, as well as thousands of secondary metabolites formed in plants and other natural organisms, there is a high trend, toward novel drug discovery from natural sources. It seems that high throughput screenings based on reverse pharmacology and reverse pharmacognosy might result in more successful approaches in the future. The main objective of this review is to exhibit an up-to-date comprehensive overview on the recently identified natural antitumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. In order to facilitate the anticancer drug discovery and development, new strategies might be considered such as biotechnology and nanoparticle targeting approaches. The reverse pharmacognosy and its complementary the reverse pharmacology which are associated with high throughput screening, virtual screening and knowledge databases from traditional medicine, provide successful and strong tools to accelerate the process of future drug discovery.
  Mohammad Hossein Asghari , Soodabeh Saeidnia and Mohammad Abdollahi
  Phthalates are a large group of chemicals, used in plasticizers and industrial solvents, to make them flexible and soluble, especially when these materials are applied in the production of toys, medical equipment and drugs coverings. It seems that phthalates induce multi-organ damage through a number of mechanisms such as oxidative stress via generation of Reactive Oxygen Species (ROS), DNA damage, lipid peroxidation, disrupting cell function and also altering the expression and activity of the most important antioxidant enzymes. In this study, we reviewed the recent publications that evaluated the contribution of oxidative stress in phthalate toxicity. Alteration of antioxidant enzymes such as a reduced SOD (Cu/Zn superoxide dismutase) activity as well as an increased CAT (catalase) function normally occur and can be observed particularly with higher doses of phthalates. Moreover, these compounds decrease GPX (glutathione peroxidase) and GST (glutathione S-transferase) activities. Nevertheless, controversy is found in the levels of cellular antioxidants like SOD showing a reduction in many organs like liver, kidney and reproductive system, whereas, its increase has been reported in a few studies. In summary, among various organs, reproductive system seems was affected further by oxidative stress through disruption of spermatogenesis, inducing mitochondrial dysfunction in gonocytes, impairment of cellular redox mechanism and increasing peroxiredoxin 3 and cycloxygenase 2 levels in spermatocytes. The phthalates are being replaced in some countries by other safe plasticizers.
  Ahmad R. Gohari , Soodabeh Saeidnia , Mahmood R. Gohari , Fahimeh Moradi-Afrapoli , Maryam Malmir and Abbass Hadjiakhoondi
  From the ethyl acetate and methanol extract of the aerial parts of Satureja atropatana Bonge, which belongs to the Lamiaceae family, four flavonoids were isolated. Their structures were determined to be 5,6,3’-trihydroxy-7,8,4’-trimethoxyflavone (1), 5,6-dihydroxy-7,8,3’,4’-tetramethoxyflavone or 5-desmethoxynobiletin (2), 5,6,4’-trihydroxy-7,8,3’-trimethoxyflavone or thymonin (3) and luteolin (4) using 1H and 13C-NMR and MS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Berberine hydrochloride (LC50 = 26 g mL-1) was used as a positive control. Among them, compounds 2 (199 g mL-1) and 3 (157 g mL-1) were effective against Artemia salina larva.
  Ahmad R. Gohari , Soodabeh Saeidnia , Maryam Malmir , Abbass Hadjiakhoondi and Yousef Ajani
  The genus Salvia (Lamiaceae) contains more than 50 shrub species in Iran, and Salvia limbata C.A. Meyer grows widely in the north and central parts of the country. Six flavones and rosmarinic acid were isolated from the ethyl acetate and methanol extracts of the flowered aerial parts of S. limbata collected from Semnan province. The separation process was carried out using several chromatographic methods. Structural elucidation was based on NMR data, in comparison with those reported in the literature. The isolated compounds were identified as ladanein (1), salvigenin (2), luteolin 7-methyl ether (3), cirsiliol (4), eupatorin (5), luteolin 7-O-glucoside (6) and rosmarinic acid (7). Some of these flavonoids have been reported to show antibacterial and cytotoxic activities.
  Seyyed Majid Bagheri , Amirhossein Sahebkar , Ahmad Reza Gohari , Soodabeh Saeidnia , Maryam Malmir and Mehrdad Iranshahi
  Several Ferula (Umbelliferae) species have been used in Iranian traditional medicine as antiflatulent, antispasmodic, anticonvulsant, expectorant, etc. In the present study, cytotoxicity and anticonvulsant activity of the methanol extracts from several Ferula species were evaluated. Air-dried samples of different parts of these plants (Ferula diversivittata Regel & Schmalh. (roots), Ferula persica Willd. (aerial parts), Ferula ovina (Boiss.) Boiss. (roots), Ferula badrakema Kos.-Pol. (roots), Ferula diversivittata (flowers), Ferula latisecta Rech. F. & Aell. (roots), and Ferula badrakema (fruits)) were macerated with methanol for 3 days. The mixtures were then filtered, concentrated and dried. For determination of the cytotoxicity of the extracts and also the oleo-gum-resin of F. assafoetida L., the brine shrimp (Artemia salina) was employed as a model assay system since it provides a convenient in-house pre-screening method for evaluating general cytotoxicity. The methanol extracts of different Ferula species and the oleo-gum-resin of F. assafoetida exhibited cytotoxic effect with LC50 values in the range of 6-321 μg/mL. For the anticonvulsant testing, seizure was induced by injection of pentylenetetrazole (PTZ), 90 mg/kg intraperitoneally (i.p.). This dose was given to 10 groups, each consisting of 6 mice, which were pretreated i.p. with the extracts (300 mg/kg), Diazepam (10 mL/kg) or saline (10 mL/kg). The results showed that none of the tested Ferula species can prevent PTZ-induced seizure at the used dose. In conclusion, all of the extracts and the oleo-gum resin of F. assafoetida showed dose-dependent cytotoxicity which was highest in F. badrakema fruits and lowest in F. badrakema roots. Our findings also revealed that the methanol extracts and F. assafoetida oleo-gum resin do not possess anticonvulsant activity.
  Fereshteh Golfakhrabadi , Seyed Nasser Ostad , Mitra Hafizi , Mohammad Reza Shams Ardekani , Soodabeh Saeidnia , Tahmineh Akbarzadeh and Mahnaz Khanavi
  Ferulago carduchorum Boiss and Hausskn (Apiaceae) is an endemic plant in West of Iran and it are used in dairy and oil ghee as a natural preservative. The aerial parts of F. carduchorum were extracted by percolation method with MeOH/H2O (80/20) and the fractions were provided respectively with hexane, ethyl acetate, methanol, methanol/H2O (50/50). The fractions have been investigated their phytochemical screening and the cytotoxic activity against the colon carcinoma (HT29), the breast ducal carcinoma (T47D), the hepatocellular carcinoma (HepG2) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT (3-(4, 5-di methyl thiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Phytochemical screening revealed the presence of phytosteroids, flavonoids, coumarins and saponins. The cytotoxicity of ethyl acetate and hexane fractions showed more efficacy than the other fractions on T47D and HepG2 cell lines (IC50<100 μg mL-1) could be attributed to their content of coumarins and phytosteroids. The hexane fraction was selected for phytochemical study and suberosin (a coumarin) isolated from hexane fraction as an active compound. The Selective Index (SI) value of ethyl acetate fraction was lower in HepG2, T47D and HT29 cell lines than hexane fraction that indicated the selective effect of ethyl acetate fraction on this cell lines.
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