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Articles by Siti Munirah Mohktar
Total Records ( 1 ) for Siti Munirah Mohktar
  Normah Awang , Siti Munirah Mohktar , Noraziah Muhammad Zin and Nurul Farahana Kamaludin
  Antibiotic resistance is a global challenge to the populations and pathogenic bacteria tends to be multiresistant towards a vast majority of antibiotics. The organotin (IV) compounds have proven to have an active biological activity as antimicrobial agent. Two series of a new compounds namely organotin (IV) ethylphenyl dithiocarbamate and butylphenyldithiocarbamate which contained 6 compounds have been tested for their antimicrobial activity using disk diffusion and microdilution tests. These compounds were tested against various microbes namely Bacillus cereus, Bacillus subtilis, Methicillin-Resistant Staphylococcus Aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter baumannii, Escherichia coli, Klebsiella sp., Shigellasonnei, Vibrio cholerae, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Microdilution test was carried out using two-fold dilution with the highest concentration of 5 mg mL-1. Results showed that compound 3 and 6 have the antimicrobial activity towards most of bacteria and fungi tested. The lowest Minimum Inhibitory Concentration (MIC) value was obtained at 39 μg mL-1 for compound 3 against V. cholerae and compound 6 against A. baumannii. Nevertheless, bacteriostatic or fungistatic effect was obtained for all compounds. In conclusion, triphenyltin (IV) dithiocarbamate compounds have a potential to act as an antimicrob agent.
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