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Articles by Simona VICAS
Total Records ( 2 ) for Simona VICAS
  Vasile LASLO , Maria ZAPARTAN , Anca KEUL-BUTIUC , Adrian TIMOFTE , Simona VICAS , Camelia BARA , Eliza AGUD and Cristina BALS
  The variety of grape-wine Fetească Neagră was tested on mediums of culture with small doses of cytokinine, in comparison with doses of five or ten times greater. The apical and nodal tissue of about 1,5-2,0 mm separated from shoots forced in growth room has been inoculated in early spring (March), on the fallowing options: Vo=MS; V1=MS1/2 +3g/l charcoal; V2=MS +1,0mg/l BA + 0,5 mg/l AIB; V3=MS+5,0mg/l BA+0,5mg/l AIB; V4=MS +10mg/l BA+0,5 mg/l AIB. Regeneration rate was monitored (after 20, 40, 60, 80 days), and also the evolution of the tissue after 80 days, with reference to shoot induction, the formation of the root system and the appearance of some atypical formations. After two months of culture in vitro we can say that the favorable variant is the one without growth hormones and with a plus of charcoal (Vo and V1), on which a smaller number of neoplantules, fully organized, have appeared, which are high and with a well-developed root system. On the variant with 10 mg/l BA have appeared about 2-3 very small plantules, of 0,5cm embedded in a mass of rhizogenic calus, unprecedented phenomenon, apparently caused by the high dose of cytokinine. The 5mg/l BA concentration from the medium generates the greater number of plants, about 12 from an explant of 2 cm with an appropriate number of roots and a calus sleeve of about 2 mm around the neoplantules.
  Dumitrita RUGINA , Simona VICAS , Mariana PETRAN , Adela PINTEA , Andrea BUNEA and Carmen SOCACIU
  In Europe, mistletoe extract (Viscum album) is widely used as complementary cancer therapies. The main active component of mistletoe extract is glycoprotein, lectin, that exhibit cytotoxic effects and immunomodulatory activities. The aim of this study was to show if the mistletoe extract, rich in phenolic acids presents anti-carcinogenic potential on A2780 tumor ovarian cells. In the first part of this study, using high performance liquid chromatography (HPLC) analysis we characterized phenolic acid content of mistletoe growing on Malus domestica. And, in the second part, we investigated whether by apoptosis on ovarian tumor cell line A2780 if anti-cancer effect of this extract mistletoe is induced. Cell proliferation was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. The A2780 cell viability was inhibited to 87% by 50 μg/ml mistletoe extract treatment, and to 79% at 110 μg/ml extract concentration. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining was performed. Cells treated with mistletoe (110 μg/ml) for 24 h displayed typical morphological features of apoptotic cells, with condensed and fragmented nuclei. Fluorimetric method was used to evaluate total reactive oxygen species content from A2780 ovarian tumor cells after mistletoe treatment. Mistletoe concentration 70μg/ml induces a significant toxic ROS-generating effect. These data indicates that the phenolic acids from mistletoe induce cell death by apoptosis on human tumor ovarian cell line, A2780.
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