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Articles by Silvia Tortorici
Total Records ( 3 ) for Silvia Tortorici
  Angelo Leone , Elvira Farina-Lipari , Aldo Gerbino , Francesco Burruano , Silvia Tortorici and Maria Buscemi
  Prostaglandins (PG) are chemical mediators for most physiological and pathological responses, including cytoprotection of the gastric mucosa, blood coagulation, inflammation and pain (1, 2, 3). E2 Prostaglandins (PG2) play an important role in the pathogenesis of periodontal diseases, since PG2 determines vasodilatation and increased vascular permeability, oedema and erythema. Therefore, it is not surprising to find high levels of PG2 in inflamed gingival tissues. Indeed, in inflamed gingival tissue, PG2 levels of the Gingival Fluid (GCF) are known to be higher in periodontitis than in healthy gingiva. Moreover, in different parodontitis the high PG2 level of the GCF is related to periodontal ligament loss. The pathogenensis of the periodontitis can be due to the high PG2 activation of the Matrix Metal-Protease (MMP), which is synthesized by monocytes and fibroblasts. Consequently, destruction of connective tissue on a large scale takes place. The aim of this research is two-fold: To test the COX-2 expression in the human epulis and study its involvement in the PG2 synthesis and to find a alternative terapy to treat gingival diseases.
  Silvia Tortorici , Francesco Burruano , Luigi Caradonna , Maria Lidia Buzzanca and Paolo Difalco
  Bisphosphonates are bone-turnover modulating drugs used to treat various diseases such as certain cancers, bone metastasis, bone- and calcium-related disorders, Paget`s disease, osteoporosis and osteopenia. Recently, several preliminary reports have reported the insurgence of osteonecrosis of the mandible and/or maxilla, associated with intravenously administered bisphosphonates. This case series describes the effects of bisphosphonates used in the treatment of certain cancers on oral bone tissues.
  Silvia Tortorici , Francesco Burruano , Emiliano Maresi , Luigi Caradonna , Paolo Difalco Angelo Leone , Maria Buscemi and Aldo Gerbino
  Eosinophilic granuloma is a proliferation of Langerhans cells in the bones that most commonly involving the skeletal system. The disease generally affects children or young adults with predominance in males and it is characterized by a single or multiple skeletal lesions. This study describes a few cases of mandibular Eosinophilic Granuloma and the effects of surgical curettage of lesions.
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