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Articles by Sihai Zhao
Total Records ( 3 ) for Sihai Zhao
  Qi Yu , Weidong Han , Yanli Wang , Kena Wei , Sihai Zhao , Penghui Yang and Liu Enqi
  The Hirsch index (h-index) originally suggested the h-index for application at the micro level. The h-index can be used not only for the lifetime achievements of a single researcher but can be applied to any (more extensive) publication set. For example, the h-index can be used for evaluating the scientific impact of journals as a robust alternative indicator that is an advantageous complement to journal impact factors. In current study, the h-index of Chinese Medical Journal and relative h-index from 1999-2008 was evaluated and compared with other two peer journals. We found that the validity of the h index should the new measure of journals be implemented.
  Wentao Sun , ChunLing Lei , Sihai Zhao , LiLun Wang , ChunChao Bi , Rui Wang , XiaoLiang Zhou , Enqi Liu and MingXia Chen
  Observation on morphological and ultrastructural changes of retinopathy in diabetic rabbit long been fed with high sucrose and fat fodders. Use alloxan to establish diabetic rabbit model. Feed the rabbits with high sucrose and fat fodders conduct a Fluorescein Fundus Angiography test (FFA) every 3~4 months to observe morphological changes in retina. Conduct Transmission Electron Microscopy (TEM) examination on eyeball of the model 10~12 months later so as to get wise to the ultrastructural changes in the rabbit retina. The FFA indicated that with the protraction of the disease, Fluorescein Isothiocyanate (FITC) leakage and neo-vasulariztion shadows similar to that of human were seen in the diabetic rabbit model. TEM examination showed that no abnormality was seen in the ultrastructure of the rabbit retina of normal group. The retina of the diabetic rabbit exhibited microfilament and focal dissolving, myelin sheath structure loosening and partial demyelination changes, pericyte mitochondrion tumefaction, endothelial cell layering, space increasing, mitochondrion tumefaction on the nerve fiber layer. Glycogenosome accumulation was seen in the outer nuclear layer retina cells.
  Guangwei Zhang , Kena Wei , Enqi Liu , Yanli Wang , Yafeng Li , Qi Yu , Yulong Chen , Bingqiao Huang , Shemin Lu , Xicai Yan and Sihai Zhao
  What the effects of rosiglitazone treatment on the fatty liver remained controversial. The aim of this study was to investigate the effects of rosiglitazone on fatty liver of rabbits. Thirty nine male Japanese white rabbits were divided into three groups, the rosiglitazone treatment Group 1 (3 mg/kg/day), rosiglitazone treatment Group 2 (6 mg/kg/day) and the control group and were fed a High Fat and Cholesterol Diet (HFCD) for 8 weeks. The Rabbit Fatty Liver Model was successfully established. HFCD resulted in a notable increase in plasma Total Cholesterol (TC) and plasma Triglycerides (TG). However, there was no significant difference among three groups in the plasma and liver parameters of TG and TC. The total body fat weight and the ratio of fat weight to body weight were higher in the rosiglitazone treatment groups vs. the control group while the ratio of the main organs and body weight were lower in the rosiglitazone treatment groups as compared to the control group. Hematoxylin and Eosin (HE) staining of liver suggested that rosiglitazone treatment led to a slight improvement of fatty liver in HFCD rabbits but the difference was not significant. The findings demonstrate that rosiglitazone treatment did not lead to significant improvement of fatty liver in rabbits.
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