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Articles by Siddig Ibrahim Abdel Wahab
Total Records ( 3 ) for Siddig Ibrahim Abdel Wahab
  Syam Mohan , Ahmad Bustamam Abdul , Siddig Ibrahim Abdel Wahab , Adel Sharaf Al-Zubairi , Manal Mohamed Elhassan and Mohammad Yousif
  Problem Statement: Multiple drug resistance in human pathogenic micro organisms has developed due to indiscriminate use of modern antimicrobial drugs generally used in the management of infectious diseases. This increases the importance of exploiting the natural sources instead modern drugs. Approach: The antibacterial and antioxidant activity of different extracts from of Typhonium flagelliforme (L.) Blume tuber (family: Araceae) commonly called ‘Rodent Tuber’ was assessed towards selected bacteria as well as in different antioxidant models. The antibacterial screening was carried out by disc diffusion method. Two complementary test systems, namely DPPH free radical scavenging and total phenolic compounds, were used for the antioxidant analysis. Results: Except hexane extract none of the other extracts shown anti bacterial activity against the selected strains. The hexane extract from Typhonium flagelliforme tuber had interesting activity against both the gram negative bacteria, Pseudomonas aeruginosa (11±1.0 mm diameter) and Salmonella choleraesuis (12±1.1 mm diameter). The positive control, Streptomycin had shown zone of inhibition of 20±1.5 mm, 20±1.3 mm, 23±1.5 mm and 23±1.0 mm in Methicillin Resistant Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella choleraesuis and Bacillus subtilis respectively. All the extracts were subjected to screening for their possible antioxidant activity. The DPPH assay showed that the inhibitory activity of ethyl acetate (77.6±0.9%) and dichloromethane (70.5±1.7%) extracts were having comparatively admirable inhibition capacity when compared to the positive control BHT (95.3±1.3%). Total phenolic content of all extracts was also evaluated, and dichloromethane extracts (5.21±0.82 GAE mg/g extract) was superior to all other extracts, followed by hexane and ethyl acetate. Conclusion: Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating antibacterial and antioxidant activity that requires further investigation.
  Siddig Ibrahim Abdel Wahab , Abdel Wahab Hassan Mohamed , Osama Yousif Mohamed , Manal Mohamed Elhassan Taha , Ahmad Bustamam Abdul and Adel Sharaf Al-Zubairi
  The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.
  Mohamed Yousif Ibrahim , Ahmad Bustamam Abdul , Siddig Ibrahim Abdel Wahab , Manal Mohammed Elhassan , Adel Sharaf Alzubairi and M.M. Syam
  Zerumbone is a natural compound isolated from the fresh rhizomes of Zingiber zerumbet. This bioactive compound has shown a chemo-preventive, anti-inflammatory and free radical scavenging activities. This study examines, the effect of zerumbone on the extent of tissue damage in Cisplatin-induced hepatotoxicity in rats. The rats received a single dose injection of 45 mg kg-1 Cisplatin. Other groups of rats received zerumbone (100 and 200 mg kg-1), corn oil or the vehicle (DMSO) intraperitoneally for 4 days prior to Cisplatin injections. All animals were decapitated 16 h after Cisplatin injection. Trunk blood was collected and analyzed for alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase and gama-glutamyl transferase. Liver tissue was kept for the quantification of malondialdehyde and glutathione levels. Histopathological investigations were carried out and severity of lesions was scored to obtain quantitative data. This study revealed that zerumbone reduced the extent of liver damage and preserved liver functions as proved by microscopic observations and lesion scoring. Increase in liver MDA levels with a simultaneous reduction in GSH in the Cisplatin 45 mg kg-1 group was attenuated by zerumbone treatment (p<0.05). Zerumbone is beneficial in Cisplatin-induced liver dysfunction and organ damage in rats via prevention of lipid peroxidation and preservation of antioxidant glutathione.
 
 
 
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