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Articles by Shyma K. Latheef
Total Records ( 4 ) for Shyma K. Latheef
  Kuldeep Dhama , Shyma K. Latheef , Saminathan Mani , Hari Abdul Samad , K. Karthik , Ruchi Tiwari , Rifat Ullah Khan , Mahmoud Alagawany , Mayada R. Farag , Gazi Mahabubul Alam , Vito Laudadio and Vincenzo Tufarelli
  Herbal medicine or herbalism is a time-honored practice of natural medicine that is older than mankind itself. The practice of using traditional herbal medicine based therapy is nowadays gaining more attention worldwide in both human and animal health care systems. Among the livestock sectors, poultry production systems are the most intensively reared with developments especially in the areas of nutrition, disease control, genetic improvement, management and organization of dietary requirements along with the pressure of increasing demand for poultry products as well as threats of emerging pathogens. So this sector is badly in need of sustainable therapeutic and production aids especially based on herbs because of the advantages like, low cost, easy availability, no residual effect, free from the threat of antibiotic resistance etc. Many herbs have been recorded to be fruitfully used by veterinarians to treat a variety of disease conditions in animals. The present study discusses the various useful and practical applications of the rich heritage of herbal wealth for safeguarding poultry health in general, combating infectious as well as non-infectious diseases caused by microbes and parasites )both ecto-and endo parasites( along with immunomodulatory actions for countering immunosuppressive diseases. Moreover, highlighting herb-based poultry growth promoters for increasing production performances use of herbs as antioxidants and their role in organic egg and meat production is a special attraction of the review that will draw the attention of the poultry specialists as well as farming community. The information will be useful to increase poultry production and protect the health of birds in a better way from traditional ways towards modern perspectives and also would promote and popularize usage of herbs amongst poultry producers.
  Kuldeep Dhama , Shyma K. Latheef , Hari Abdul Samad , Sandip Chakraborty , Ruchi Tiwari , Amit Kumar and Anu Rahal
  Signaling molecules of immune system are cytokines that may either stimulate or suppress the responses of various cells involved in host immune mechanisms and Tumor Necrosis Factor (TNF) is one of the leading members of the group of cytokines. TNF-α from activated macrophages and LT-α/TNF-Β from T cells have now become representatives of a distinctive superfamily of cytokine ligands (TNF ligand superfamily) along with their corresponding receptors (TNF receptor superfamily); altogether constituting the TNF Superfamily. These are highly conserved proteins, found in all mammals having important ligand members which interact with the either of the two receptors, TNFR1 and TNFR2, that initiate varied signaling cascades leading to diverse cellular responses. It has been established that the appropriate regulation of TNF ligand and receptor interactions and functions are crucial for the proper immune system activity. Excessive production of various TNF cytokines has been attributed with the development of an array of autoimmune as well as inflammatory conditions. TNF cytokines help to reduce mortality due to cardiovascular diseases. Therapeutic TNF blockers include:monoclonal antibodies to TNF (Infliximab and Adalumimab) and TNF receptor fusion proteins (Etanercept and Lenercept) and are effective against rheumatoid arthritis; ankylosing spondylitis; psoriasis and asthma. Preclinical studies conducted in murine models and the pivotal role played by the TNF superfamily in cytokine mediator system will make it easier for researchers as well as scientists to develop novel drugs in near future. This review has covered all these aspects concerning TNF as mediator of inflammatory diseases and its therapeutic targeting.
  Kuldeep Dhama , Sandip Chakraborty , Ruchi Tiwari , Amit Kumar , Anu Rahal , Shyma K. Latheef , Mohd Yaqoob Wani and Sanjay Kapoor
  Avian/Bird flu, caused by Avian Influenza Virus (AIV) belonging to Orthomyxoviridae family, is the most fearful viral disease of birds. H5N1 subtype of AIV is of major concern for poultry as well as for humans due to its high economical impacts and zoonotic concerns. During the past ten years, the Highly Pathogenic Avian Influenza (HPAI) H5N1 subtype alone has affected more than 60 countries of the world. Domestic poultry is mostly affected by the disease episodes and outbreaks. Wild and migratory birds are the AIV reservoirs wherein H5N1 is found to be lethal. Major antigenic changes in Haemagglutinin (HA) or Neuraminidase (NA) result in periodic pandemics. Pigs can act as mixing vessel. The bird flu virus if gets the capability of transmitting from human to human can trigger a pandemic claiming millions of lives. A wide variety of serological tests and molecular tools have greatly aided in the diagnosis of avian flu. Disease management for the prevention of bird flu outbreaks including mass awareness and pandemic preparedness following World Health Organization (WHO) guidelines is of utmost importance. Interesting approaches of HPAI control are development of universal influenza virus vaccines and universal antibodies-based flu therapies. Vaccination using inactivated and recombinant vaccines is the common strategy adopted in different parts of the globe. Development of new generation vaccines is quiet noteworthy. Tamiflu is the drug of choice. Herbal therapy is gaining much attention to control disease in humans. All these aspects of the bird flu virus have been discussed vividly in the present review.
  Mohd Yaqoob Wani , Kuldeep Dhama , Shyma K. Latheef , Rajamani Barathidassan , Ruchi Tiwari , Sandip Chakraborty , Milind Madhukar Chawak and Shambhu Dayal Singh
  Chicken Infectious Anaemia Virus (CIAV) is one of the potent immunosuppressive and economically important agents affecting poultry industry worldwide. Recent reports indicate the emergence of this virus in the poultry flocks of the country. The present study aimed to investigate the pathogenic potential of a recent isolate of CIAV obtained from poultry flock of Uttaranchal State, India. Twenty first day-old age Specific Pathogen Free (SPF) chicks were inoculated intramuscularly with 104.5 median tissue culture infective dose (TCID50) of CIAV passaged in the Marek’s disease virus transformed chicken splenic T lymphocyte (MDCC-MSB1) cell line while 15 chicks were kept as control. The CIAV isolate produced consistent clinical signs, loss in body weight gain, anaemia, low haematocrit values, bone marrow aplasia and generalized lymphoid atrophy. Mean Packed Cell Volume (PCV) value of the infected chicks was significantly low (18.22±2.22) compared to control group (34.12±4.72) at 14 day post infection (dpi). The establishment of virus infection in chicks was confirmed both at molecular and antigenic levels by Polymerase Chain Reaction (PCR) and Indirect Immunofluorescent Test (IIFT), respectively. Characteristic apoptotic pattern was also detected in the affected organs and the virus was re-isolated successfully in MDCC-MSB1 cell cultures. The present results revealed that the virus circulating in poultry flocks of Uttaranchal state is both pathogenic and immunosuppressive in nature. Extensive epidemiological studies are suggested in the poultry flocks of the country along with adaptation of appropriate diagnostic, prevention and control strategies so as to prevent economic losses caused by this important poultry pathogen.
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