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Articles by Shonia Subramaniam
Total Records ( 2 ) for Shonia Subramaniam
  Shonia Subramaniam , Ammu Radhakrishnan , Srikumar Chakravarthi , Uma Devi Palanisamy and Nagaraja Haleagrahara
  This study investigated the antidiabetic effects of the rind of Nephelium lappaceum extract in a high fat-induced diabetic rat model. Ethanolic N. lappaceum rind extract was prepared and standardised with geraniin using high performance liquid chromatography. Male Sprague Dawley rats were fed on a high fat diet followed by 210 mg kg–1 nicotinamide and 55 mg kg–1 streptozotocin injection to induce type 2 diabetes. The diabetic rats were treated with N. lappaceum rind at concentrations of 500 and 2000 mg for 28 days. Positive control rats were treated with 200 mg metformin. A 41.1% yield of ethanolic extract was obtained from powdered N. lappaceum rind while geraniin present in the extract was quantified to be 33.0±0.2 mg geraniin/g extract. Our study also showed that the diabetic rats treated with 2000 mg N. lappaceum had reduction in blood glucose level and improved insulin levels which were similar to the metformin-treated group. Pancreas histology showed that the group treated with 2000 mg of N. lappaceum had healthy pancreas morphology and the treatment was comparable to the effects observed in the metformin-treated group. In conclusion, N. lappaceum rind extract showed anti-hyperglycaemic activity at a dose of 2000 mg kg–1 without any major toxic effects in high-fat diet induced diabetic rats.
  Shonia Subramaniam , Srikumar Chakravarthi , Uma Devi Palanisamy , Ammu Radhakrishnan and Nagaraja Haleagrahara
  Nephelium lappaceum is a tropical fruit native to Malaysia. The rind of N. lappaceum, is having extremely high antioxidant and free radical scavenging activities. The ethanol extract from the rind of Nephelium lappaceum was evaluated for acute and sub-chronic toxicity study in Sprague Dawley rats. In the acute study, a single oral administration of N. lappaceum rind extract (50, 200, 1000 and 2000 mg kg-1) was administered to rats for 14 days. In the sub chronic toxicity study, the extract was administered to rats (500, 2000 mg kg-1) for 28 days. There was no mortality, or adverse effects observed in rats. There was no significant difference observed in relative organ weights and the biochemical analysis (serum urea, creatinine, ALP, AST and total protein). Histological observation of liver and kidney also did not reveal any significant changes. In conclusion, present study showed that the lethal dose of ethanol extract of Nephelium lappaceum rind is more than 2000 mg kg-1 and there is a huge margin of safety for the therapeutic use. No-observed-adverse-effect-level (NOEL) of the extract is considered to be up to 2000 mg kg-1 day-1 for 28 days in rats.
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