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Articles by Shokoufeh Hassani
Total Records ( 2 ) for Shokoufeh Hassani
  Mojdeh Mohammadi , Shokoufeh Atashpour , Nazila Pourkhalili , Amir Nili-Ahmadabadi , Maryam Baeeri , Azadeh Mohammadirad , Shokoufeh Hassani , Shekoufeh Nikfar and Mohammad Abdollahi
  Increased oxidative stress plays a role in the pathogenesis of cellular death and β-cell failure. The aim of this study was to evaluate the action of different types of phosphodiesterase (PDE) inhibitors including milrinone (PDE-3), rolipram (PDE-4) and sildenafil (PDE-5) on viability, production of Reactive Oxygen Species (ROS) and secretion of insulin from isolated rat pancreatic islets. Pancreatic islets were carefully isolated and incubated in RPMI 1640 for 24 h. After overnight incubation, islets were picked up and divided into ten in each groups. Then, milrinone, rolipram and sildenafil at doses of 0.1, 1, 10 and 100 FM were added to islet groups and incubated for further 24 h. Then static insulin secretion at 2.8 and 16.7 mM concentrations of glucose, was tested. Then the viability of cells, level of ROS and insulin were examined. The results of static experiments showed that secretion of insulin increased significantly in response to glucose at both basic (2.8 mM) and stimulation (16.7 mM) levels by the lower doses of tested PDE inhibitors. The level of ROS at the lower doses of milrinone decreased. The viability of islets at the lower doses of all of PDE inhibitors were increased; however, viability at the higher doses of sildenafil and rolipram reduced significantly. Milrinone was the most effective PDE inhibitors on the function of isolated pancreatic islets. PDE inhibitors show the most significant anti-oxidative effects at lower doses. Concerning improvement of isolated islets function, PDE-3 inhibitor is the best among tested compounds. PDE inhibitors may help management of diabetes and facilitate conditions of islet transplantation.
  Amir Baghaei , Neda Hajimohammadi , Maryam Baeeri , Azadeh Mohammadirad , Shokoufeh Hassani and Mohammad Abdollahi
  Aluminum phosphide (AlP) intoxication is becoming a major concern worldwide due to its high mortality rate (30-100%) besides non-availability of effective antidote till date. The aim of present study was to determine the effect of IMOD, a novel mixed herbal medicine on energy depletion, oxidative stress and change of electrocardiographic (ECG) parameters in the heart tissue of the rats poisoned by AlP. IMOD at doses of 13, 20 and 30 mg kg-1 was administered intraperitoneally 30 min after gavage intragastric administration of AlP (0.25 LD50). Sodium bicarbonate was used as the control. After anesthesia, animals were rapidly connected to PowerLab® device for monitoring of ECG, blood pressure and heart rate for 180 min. At 24 h post treatment, rats were decapitated and hearts removed for evaluation of oxidative stress markers and production of energy. AlP ingestion led to significant heart rate and blood pressure decrement as well as ST variation and shortening of PR interval. Administration of IMOD normalized AlP-disturbed cardiovascular parameters. IMOD also restored heart energy via re-establishment of cellular ATP pool and elimination of oxidative stress markers. These findings confirm the potential benefits of IMOD as an effective treatment for acute AlP poisoning that remain to be trialed clinically.
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