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Articles by Shirin Hasani-Ranjbar
Total Records ( 4 ) for Shirin Hasani-Ranjbar
  Shirin Hasani-Ranjbar , Somayeh Khosravi , Neda Nayebi , Bagher Larijani and Mohammad Abdollahi
  This review focuses on the efficacy and safety of medicinal plants which have been utilized in traditional medicine for anti-aging purpose. All relevant databases were searched for the terms “anti-aging” and “herbs” or “medicinal plant” without limitation up to 30th January 2011. All the clinical and non-clinical studies with the outcome of change in aging process were included. Search in databases resulted in 1733 articles that on the basis of inclusion/exclusion criteria, 67 studies were finally included. Six human and 61 animal studies were reviewed for the effect of anti-aging herbs on aging process. Most of the studies showed significant improvement in brain function (memory, cognitive, anxiety), sexual disorder and skin wrinkle. From the performed studies, the exact mechanism of anti-aging action and side effect cannot be concluded and thus further studies would be helpful.
  Shirin Hasani-Ranjbar , Neda Nayebi , Bagher Larijani and Mohammad Abdollahi
  This review focuses on the efficacy and safety of Teucrium species that are effective in the management of different conditions in human and animal. Embase, Scopus, Pubmed, Google Scholar and IranMedex databases were searched up to 11th May 2009. The search terms were Teucrium or germander or Calpoureh. All of the human and animal studies considered the effects of Teucrium with the key outcome of change in blood glucose, serum lipids, anti-oxidant parameters, hepatic enzymes, anti-inflammation, analgesic effects, anti-ulcer effects anti-microbial effect and toxic effects were included. Studies performed on cell lines, in vitro studies, reviews and letters to editors were excluded. Of initial search, 7325 record were reviewed for inclusion or exclusion in study. Finally, 68 studies were included. Some animal and one human study showed hypoglycemic effects of Teucrium. In one animal study, Teucrium decreased serum cholesterol and triglyceride in hyper-lipidemic rats. Some studies indicated anti-oxidant, anti-spasmodic, anti-nociceptive and anti-inflammatory properties of Teucrium. According to histopathological and biochemical evidences, high doses or long-term administration of Teucrium may induce progressive impairment of neuromuscular coordination and reversible or irreversible hepatic damage. Teucrium has antidiabetic effect by enhancing secretion of insulin from the pancreas. The flavonoids and sterols are responsible for the anti-inflammatory activity of this plant. Isolation and characterization of Teucrium constituents is suggested to reach suitable drugs.
  Avin Mehri , Shirin Hasani-Ranjbar , Bagher Larijani and Mohammad Abdollahi
  This review focuses on the efficacy and safety of Urtica dioica which has been utilized in traditional medicine for management of diabetes. All relevant databases including Pubmed, Google Scholar, Web of Science, Scopus, Iranmedex and MD Consult were searched for the terms diabetes mellitus and Urtica dioica without limitation up to 15th September 2010. All the animal studies with the outcome of change in blood glucose or other relevant complications of diabetes and all available abstracts were included. Review articles and letters to the editor were excluded. Search of databases resulted in 724 articles which 87 were potentially relevant studies on Urtica dioica and diabetes. On the basis of inclusion/exclusion criteria, 21 studies were finally included. One human and 20 animal studies were reviewed for the efficacy of Urtica dioica. Most of these studies showed significant decrease in blood glucose and complications of diabetes by use of Urtica dioica. Urtica dioica can affect both pancreatic and extra pancreatic pathways. Available evidences suggest that Urtica dioica can be used to treat diabetes and its long-term complications. Of course, further experiments would help determine exact mechanisms of action, effects and side effects of this herbal medicine.
  Shilan Mozaffari , Shirin Hasani-Ranjbar and Mohammad Abdollahi
  Dyslipidemia and following atherosclerosis as a chronic affection remain one major cause of death all over the world. Given multiple reports on positive effects of melatonin on dyslipidemia, there is a need for reviewing all these studies in order to reach a convincing conclusion. Towards this goal, we have reviewed all previous investigations on use of melatonin in dyslipidemia found from PubMed, Cochrane, Google Scholar, Scopus and web of Science up to January 2012. Of the publications identified in the initial database, 11 clinical trials and 43 nonclinical trials (18 in vitro and 25 animal studies) were included and reviewed. Most of the results reveal the potency of melatonin as an antioxidant in preventing lipid peroxidation through different mechanisms and therefore, improving the lipid profile. Melatonin has anti-inflammatory and antioxidative effects, neutralizes free radicals, increases antioxidative enzymes and glutathione levels, prevents electron leakage from the mitochondrial respiratory chain, acts synergistically with vitamin C, E and glutathione, reduces levels of pro-inflammatory cytokines and therefore prevents Low-density Lipoprotein (LDL) oxidation and decreases lipid peroxidation. The results indicate a need for further studies on safety/efficacy measures if melatonin was used in long-term.
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