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Articles by Shilan Mozaffari
Total Records ( 3 ) for Shilan Mozaffari
  Seyedeh Farnaz Ghasemi-Niri , Sara Solki , Tina Didari , Shilan Mozaffari , Maryam Baeeri , Mohammad Amin Rezvanfar , Azadeh Mohammadirad , Hossein Jamalifar and Mohammad Abdollahi
  Alteration of intestinal microflora has an important role in Inflammatory Bowel Disease (IBD) and probiotics by balancing microflora and modulating inflammatory cytokines seem effective in management of IBD. In the present study, two combinations of probiotics Lactobacillus casei (L. casei) plus Bifidobacterium bifidum (B. bifidum) or plus Saccharomyces boulardii (S. boulardii) were tested for their potential to prevent or treat experimental colitis in rats. Nine groups of animals including sham (normal group), control (vehicle-treated), dexamethasone as standard, treatment groups (oral administration of L. casei and mixture of (L. casei-B. bifidum and L. casei-S. boulardii after induction of colitis) and prevention groups (oral administrations of L. casei and mixture of (L. casei-B. bifidum and L. casei-S. boulardii before induction of colitis) were used. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) and lipid peroxidation (LPO) were determined in all groups. In treatment groups, histological scores and TNF-α, MPO and LPO levels attenuated significantly but colonic lesions in the prevention groups did not recover. The results revealed that, combination of L. casei-B. bifidum and L. casei-S. boulardii alleviated inflammatory parameters in colitis but these combinations were ineffective to prevent colitis. In addition, we found that mixture of probiotics is significantly more effective than L. casei group in improving barrier function of epithelium in experimental colitis model.
  Shilan Mozaffari , Shirin Hasani-Ranjbar and Mohammad Abdollahi
  Dyslipidemia and following atherosclerosis as a chronic affection remain one major cause of death all over the world. Given multiple reports on positive effects of melatonin on dyslipidemia, there is a need for reviewing all these studies in order to reach a convincing conclusion. Towards this goal, we have reviewed all previous investigations on use of melatonin in dyslipidemia found from PubMed, Cochrane, Google Scholar, Scopus and web of Science up to January 2012. Of the publications identified in the initial database, 11 clinical trials and 43 nonclinical trials (18 in vitro and 25 animal studies) were included and reviewed. Most of the results reveal the potency of melatonin as an antioxidant in preventing lipid peroxidation through different mechanisms and therefore, improving the lipid profile. Melatonin has anti-inflammatory and antioxidative effects, neutralizes free radicals, increases antioxidative enzymes and glutathione levels, prevents electron leakage from the mitochondrial respiratory chain, acts synergistically with vitamin C, E and glutathione, reduces levels of pro-inflammatory cytokines and therefore prevents Low-density Lipoprotein (LDL) oxidation and decreases lipid peroxidation. The results indicate a need for further studies on safety/efficacy measures if melatonin was used in long-term.
  Shilan Mozaffari and Mohammad Abdollahi
  The condition of activated inflammation in the intestine is known as Necrotizing Enterocolitis (NEC) which is more frequent in premature infants. Various studies have being carried out to find effective protections or therapies based on recognized pathophysiology of the disease. In the present review, all possible mechanisms and existing evidences at experimental or clinical levels have been analyzed. The main target is the modulation of inflammation by use of immune modulators and anti-oxidants. Pentoxifylline (Ptx) exhibits immunomodulatory effects via decreasing the synthesis of tumor necrosis alpha (TNF-α), interlukin-6 (IL-6), interferon-gamma (INF-γ) and other pro-inflammatory cytokines. It exerts anti-oxidant properties via scavenging hydroxyl radicals and inhibiting the xanthine oxidase. Therefore Ptx is deemed an option in the management of NEC in premature infants if proper clinical trials confirm its safety in neonates.
 
 
 
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