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Articles by Sharon C. A. Chen
Total Records ( 2 ) for Sharon C. A. Chen
  Peter Troke , Koldo Aguirrebengoa , Carmen Arteaga , David Ellis , Christopher H. Heath , Irja Lutsar , Montserrat Rovira , Quoc Nguyen , Monica Slavin and Sharon C. A. Chen
  The efficacy of voriconazole in 107 patients with scedosporiosiswas analyzed. Principal infection sites were the lungs/sinuses(24%), central nervous system (CNS) (20%), and bone (18%), while21% of patients had disseminated infection. Solid organ transplantation(22%), hematological malignancy (21%), and surgery/trauma (15%)were the predominant underlying conditions. A successful therapeuticresponse was achieved in 57% of patients (median, 103 therapydays), with >98% of those responding receiving >=28 days oftherapy. Patients receiving primary therapy showed a 61% responseversus 56% for the others. The best therapeutic responses wereseen for skin/subcutaneous (91%) or bone (79%) infections, andthe lowest for CNS infections (43%). Patients without majorimmune suppression (72%) or those with solid organ transplantation(63%) or various hematological conditions (60%) showed the bestresponses by underlying condition. Median known survival timewas 133 days (therapy successes, 252 days; failures, 21 days).In all, 43 (40%) patients died, 73% due to scedosporiosis. Patientswith Scedosporium prolificans infection had significantly reducedsurvival times (P = 0.0259) and were more likely to die fromfungal infection (P = 0.002) than were Scedosporium apiospermum-infectedpatients. In a subset of 43 patients where voriconazole baselineMICs were available, response to voriconazole was higher forS. apiospermum-infected patients (54% response; MIC50, 0.25µg/ml) than for S. prolificans-infected patients (40%response; MIC50, 4.0 µg/ml). Voriconazole demonstratedclinically useful activity in the treatment of both S. apiospermumand S. prolificans infections and was well tolerated.
  Xiaoyong Zhou , Fanrong Kong , Tania C. Sorrell , Hui Wang , Yiqun Duan and Sharon C. A. Chen
  A sensitive rolling-circle amplification (RCA)-based method utilizing species-specific padlock probes targeted to the internal transcribed spacer 2 region of the fungal ribosomal DNA gene complex was developed. The assay was rapid (2 hours) and specific. Of 28 fungal isolates (16 of Candida, six of Aspergillus, and six of Scedosporium spp.), all were all identified correctly.
 
 
 
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