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Articles by Sharif Mohammad Shaheen
Total Records ( 2 ) for Sharif Mohammad Shaheen
  Sharif Mohammad Shaheen , Md. Nazir Hossen , Kazi Mehedul Islam , Maruf Ahmed , Md. Shah Amran and Mamunur Rashid
  In order to evaluate the feasible application of bio-adhesive polymers like HPMC-15 cps and 50 cps; gelatin; Na-CMC and xantham gum in sustained release dosage form (SRDF), tablets containing various amount of bio-adhesive polymers with a model drug like anhydrous Theophylline sodium glycinate were prepared by compression in a hydraulic press (Perkin Elmer) compression machine using 5 ton pressure. The release characteristics of Theophylline (TH) from sustained release tablets were analyzed in triplicate using a thermal shaker (Memmert) with a shaking speed of 50 rpm at 37±0.5°C in 250 mL of simulated gastric fluid without enzyme for 8 h. At the end of 8 h of dissolution it was found that 61.60% (for 300 mg HPMC-15 cps) and 42.92% (for 500 mg HPMC-15 cps) of TH was released from HPMC-15 cps based tablets, respectively. When HPMC-15cps was increased to 50 cps, 52.12 and 59.66% of TH was released, respectively. Both concentration and viscosity depended sustained release of TH was found. 74.13 and 94.15% of TH was released from Gelatin based SR tablets of the same concentrations, respectively. Gelatin also showed the same concentration effects i.e. release was reduced with an increase in concentration of polymer. 52.40 and 50.95% of TH was released from Na-CMC based SR tablets of the same concentrations, respectively and that of 76.96 and 78.26% of TH from xanthan gum based tablets. It means that there was no remarkable concentration effect of these two polymers on the TH release. In all cases there was almost zero order release fashion. Bio-adhesive polymers like HPMC and gelatin might be successfully applicable in SRDF rather than Na-CMC and xanthan gum studied here.
  Sharif Mohammad Shaheen , Abdul Khalek Molla , Maruf Ahmed and A.K.M. Motahar Hossain
  Applications of various percentages (0, 2, 4, 8, 12 and 16%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Naproxen (NP) from Polyethylene Glycol 4000 (PEG)-based suppositories were studied in order to reduce rectal mucosal damage and also to investigate their release pattern. Naproxen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of NP and almost 65% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Two percent GMS containing PEG-based suppositories liberated about 69.0% of the drug within 6 h whereas maximum 45.0 and 32.0% of drug were liberated from % SA and % CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order CA>SA>GMS. Utilizing this capability of the additives, sustained release suppositories of Naproxen could be formulated.
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