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Articles by Sharif Akhteruzzaman
Total Records ( 3 ) for Sharif Akhteruzzaman
  Sebok Kumar Halder Halder and Sharif Akhteruzzaman
  Allele frequency of three Short Tandem Repeats (STR) loci, D16S539, D7S820 and D13S317 were analyzed by PCR amplification and polyacrylamide gel electrophoresis in 52 unrelated Bangladeshi individuals. A GenePrint™ SilverSTR™ Triplex kit (Promega Corporation, USA) was used in this study. All STR loci were in Hardy-Weinberg equilibrium. Statistical parameters for forensic importance, the Power of Discrimination (PD), observed and expected Heterozygosity values (H), Polymorphism Information Content (PIC), Probability of Match (PM), Power of Exclusion (PE) and typical Paternity Index (PI) were calculated for the loci. These parameters indicated the usefulness of the loci in paternity testing and personal identification in Bangladeshi population. The combined Probability of Match (PM) and using the three loci was 3.88 x 10-4 and hence the PD (1-PM) was 0.99961. The combined power of exclusion for paternity for the three loci was also calculated at greater than 0.9396.
  Minhaz Uddin Ahmed and Sharif Akhteruzzaman
  Apolipoprotein (Apo E) gene polymorphism was determined in 53 unrelated Bangladeshi individual by using restriction enzyme isoform genotyping. This gene is polymorphic, with three common alleles coding for three major isoforms ε2, ε3 and ε4, resulting in six genotypes (ε2/ε2, ε3/ε2, ε4/ε2, ε3/ε3, ε4/ε3 and ε4/ε4). These isoforms differ from each other by a single amino acid substitution. Apo E functions as ligands of various receptors and determines the metabolic fate of lipoproteins. The genetic variations at the Apo E locus could thus be a major determinant of the inter-individual variation in susceptibility to coronary artery disease. The allele frequencies for Apo ε2, ε3 and ε4 alleles were found to be 0.05, 0.80 and 0.15, respectively in Bangladeshi population. The allele frequencies found in this study were compared with other Asian populations using Chi-square (χ2) test and cluster analysis. The Bangladeshi population shows close relationship with Japanese population living in Tokyo, Sendai and Indian populations living in Singapore. This study found ε3 to be the predominant isoform but the relative proportions of the three isoforms have shown variation among populations.
  Mesbah Uddin , Mashiul Azam , Nizamudddin Chowdhury and Sharif Akhteruzzaman
  Angiotensin-I Converting Enzyme (ACE), a major component of the Rennin-Angiotensin System (RAS) regulates the renal hemodymamics of our body. An insertion/deletion (I/D) polymorphism of ACE gene has been implicated in kidney disease, hypertension and cardiac function. In the present study, we investigated I/D polymorphism of ACE gene in 125 subjects of both sexes, consisting of 66 normal controls and 59 type 2 diabetic patients with nephropathy. The allele and genotype frequency were significantly different between the patients with diabetic nephropathy and control groups (p<0.001). In the nephropathic patients, ID and DD genotypes were present in 37.2 and 40.6% of patients respectively as compared to 42.4 and 21.2% in those of control groups. The D allele was present in 55.5% of the nephropathic patients and 44.4% of the normal controls. Therefore, percentage of DD genotype and D allele was significantly higher in nephropathic patients compared to normal controls.
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