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Articles by Shanthy Sundaram
Total Records ( 3 ) for Shanthy Sundaram
  Pranati , Sanjiva Bimal , K. Pandey , P.K. Sinha , A.K. Gupta , Shubhankar K. Singh , Shanthy Sundaram and P. Das
  Cytokine behavior of T-lymphocytes is not very clear when a patient is co-infected with Leishmania donovani and HIV. To achieve this we studied groups of patients comprising of VL infected, HIV infected and HIV-VL co-infected cases. As compared to lone infections by either of the infecting agent, the co-infection cases showed greatly diminished CD4 T-cell counts and slightly enhanced values of cytokines (IFNγ and IL4). The effect of 63 KDa antigenic fraction of L. donovani, previously reported by our group as having potential immunoprophylaxis effects, was also studied for its effect on T-cell cytokine pattern in the co-infection cases. It was interesting to find that this antigenic fraction showed an increase in the proportion of CD4 T-cells secreting IFNγ in both VL (alone) and HIV-VL co-infection groups.
  Shanthy Sundaram and K.K. Soumya
  Combining nitrogen fixation with other bacterial metabolic capabilities to convert the waste carbon into useful raw materials would be a highly desirable further enhancement to the process. To study the possibility of further enhancement of the value proposition of waste remediation from cost-neutrality to profitability, we can use nitrogen-fixing or non nitrogen fixing cyanobacteria that also naturally accumulate effluent from remediating materials. A filamentous heterocystous cyanobacterium, Nostoc muscorum, unicellular-non heterocystous cyanobacterium, Synechococcus PCC 7942, filamentous non heterocystous cyanobacterium, Spirulina platensis and heterocystous filamentous cyanobacterium Anabaena cylindrica, have the ability to degrade industrial pollutants such as benzene, toluene and xylene. We have done the growth measurements and estimated the amount of pigments like chlorophyll-a, carotenoids, phycocyanin. We also have studied the accumulation of total peroxide radicals and lipid peroxidation due to accumulation of MDA and stress busters such as ascorbate, proline, glutathione etc under all the above stress. Total antioxidant activity of cyanobacteria is measured by TBARS assay. We have also studied the enzymes involved in the antioxidant mechanism like superoxide dismutase and peroxidase. The amount of pigments started decreasing as the concentration of the stress increased. But, the amount of ascorbate and proline and other antioxidant activities increased under stress. This suggests that cyanobacteria may be able to survive under organic stress. Biodegradation is increasingly being considered as a less expensive alternative to physical and chemical means of decomposing organic pollutants. Biosensors may be designed to indicate and estimate pollutants in natural wastes, using PS2 particles/ thylakoids/spheroplasts.
  Shanthy Sundaram , Priyanka Dwivedi and Shalini Purwar
  The present aim of study is to detect the antibacterial property in the extracts of Withania somnifera. The antibacterial activity of Withania somnifera was tested on clinically isolated bacterial pathogens, i.e., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis causing infections in human beings. Different solvents as ethanol, ethyl acetate, dichloromethane, hexane (from higher polarity to lower polarity) extracts was used for the study of antibacterial activity, by agar well diffusion method. The bacterial plates were prepared by nutrient agar. The extracts at different concentration from 10 to 40 mg mL-1 were loaded in the wells prepared in nutrient agar. Zone of inhibition was measured around the wells to check the antibacterial activity of extracts. Results showed the polar solvents to have higher antibacterial property in comparison to the nonpolar solvents. Relatively higher Minimum Inhibitory Concentration (MIC) were obtained for both gram positive bacteria S. aureus, B. subtilis and gram negative bacteria, E. coli and P. aeruginosa, with polar extract; however, less inhibitory effect was noted for nonpolar extracts. Ethyl acetate extract possesses great inhibitory activity for gram positive bacteria, S. aureus followed by B. subtilis. Among gram negative bacteria, highest inhibitory effect was observed with P. aeruginosa followed by E. coli. Antimicrobial activity of crude extract of W. somnifera were carried out to validate the use of traditional medicinal herbal and the results of this study tend to give credence to the common use of W. somnifera plant.
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