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Articles by Shan Chen
Total Records ( 3 ) for Shan Chen
  Shan Chen
  Artificial immune algorithm is a kind of intelligent learning algorithm which simulates the biology immunity systems and is widely applied in anomaly detection. There are many techniques for anomaly detection. Among these approaches, Multilevel Immune Learning Algorithm (MILA) is a prominent one due to better discrimination ability and a higher detection rate. However, the limitation of MILA is the T suppressor (Ts) detector generation mechanism which fails to match the coverage of the high-dimensional self space well. In comparison with MILA, an optimized multilevel immune learning algorithm is presented. The optimized algorithm takes a novel variable-recessive threshold model into the process of detector generation and achieves a better coving effect. The experimental results indicate that the optimized algorithm is useful to the anomaly detection with very good detection rate and lower false alarm rate.
  Shan Chen , Zhong Zheng and Pingsha Huang
  This study introduced the distribution and the development of bamboo industry in Anji Country, Zhejing Province of China and analyzed the problems of bamboo industry in resource utilization and environmental impact in Anji Country. Based on the analysis, the main findings of the environmental issues of bamboo industry were inefficient utilization of bamboo resource, discharge of unthreatened wastewater and large amount of solid wastes, while the process dust, air pollutants emission from fuel gas and noise could meet the related national standards. Bamboo industry, as a traditional industrial sector, plays an important role for local economic growth not only from its merchandise value but also from its nice scenery. In order to dealing with these environmental issues for the local sustainable development the author proposed the strategies for multiple use of bamboo resource as a whole, from the bamboo cultivation management, bamboo products to waste management. The suggestions included bamboo fabric products and bamboo leave flavonoids development, bamboo charcoal as a new energy product and pollution emission control measurement. From the circular economic point of view, ecological industry park could be a model for bamboo industry. Therefore, industrial chain design and development ideas were described as well in the paper. The study was useful for Anji bamboo industry to achieve the realization of circular economy as well as sustainable development.
  Rujun Gong , Abdalla Rifai , Yan Ge , Shan Chen and Lance D. Dworkin
  Activation of NFκB is a fundamental cellular event central to all inflammatory diseases. Hepatocyte growth factor (HGF) ameliorates both acute and chronic inflammation in a multitude of organ systems through modulating NFκB activity; nevertheless, the exact molecular mechanism remains uncertain. Here we report that HGF through inactivation of GSK3β suppresses NFκB p65 phosphorylation specifically at position Ser-468. The Ser-468 of RelA/p65 situates in a GSK3β consensus motif and could be directly phosphorylated by GSK3β both in vivo and in vitro, signifying Ser-468 of RelA/p65 as a putative substrate for GSK3β. In addition, the C terminus of RelA/p65 harbors a highly conserved domain homologue of the consensus docking sequence for GSK3β. Moreover, this domain was required for efficient phosphorylation of Ser-468 and was indispensable for the physical interaction between RelA/p65 and GSK3β. HGF substantially intercepted this interaction by inactivating GSK3β. Functionally, phosphorylation of Ser-468 of RelA/p65 was required for the induced expression of a particular subset of proinflammatory NFκB-dependent genes. Diminished phosphorylation at Ser-468 by HGF resulted in a gene-specific inhibition of these genes` expression. The action of HGF on proinflammatory NFκB activation was consistently mimicked by a selective GSK3β inhibitor or GSK3β knockdown by RNA interference but largely abrogated in cells expressing the mutant uninhibitable GSK3β. Collectively, our findings suggest that HGF has a potent suppressive effect on NFκB activation, which is mediated by GSK3β, an important signaling transducer controlling RelA/p65 phosphorylation specificity and directing the transcription of selective proinflammatory cytokines implicated in inflammatory kidney disease.
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