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Articles by Shama I.Y. Adam
Total Records ( 2 ) for Shama I.Y. Adam
  Shama I.Y. Adam , Nesreen Alsanousi , Ahdaf M.A. Ahmed , Sahar Y. Ali , Maiada M. Abdallah , A.A. Anfal and Sara M. Hamed
  Background and Objective: Tribulus terrestris, a plant of Zygophyllaceae family have been widely used in folk medicine for the treatment of urinary stones, circulatory system problem, intestinal parasitic worms and for skin disorders and many other body ailments. In Sudan, it is traditionally used to remove the urinary tract stones. The present study aimed to evaluate the potential toxicity of T. terrestris fruits on Wister rats by using three different doses in 8 weeks. Materials and Methods: The rats were allocated into 4 groups, each of 6 rats. Group 2,3 and 4 rats were fed a diet containing different concentrations of Tribulus terrestris plant. The mortality and weight gain, sero-biochemical and hematological parameters were recorded in addition to determination of lipid profile and pathological changes. In addition, the anti-microbial activity of T. terrestris fruits methanolic extract were tested against two Gram+ve bacteria (Staphylococcus aureus, Bacillus subtitles), three Gram-ve bacteria (Salmonella sp., Proteus vulgaris, Escherichia coli) and Candida albicans. Results: The results showed no significant changes observed in all the measured parameters including serum lipid profile, hematological and sero-biochemical parameters, they were not significantly different from the control group. In addition, histopathological examination revealed no lesions observed on the vital organs namely, liver, kidney and intestine. Methanolic extracts from the fruits of T. terrestris showed a broad spectrum of anti-microbial activity against tested pathogens. Conclusion: The characteristic traits of T. terrestris fruits are not toxic and found to be a save alternative to be used in the treatment of various diseases.
  Shama I.Y. Adam and S.E.I. Adam
  The effects on rats of the aqueous and methanol extracts prepared from Rhanterium epapposum and Trichodesma africanum aerial parts, given at different dose levels (300, 75 mg/kg/day) and by different routes of administration (orally or intra muscularly (i.m.) were investigated. The results indicated that the plant extracts are toxic and lethal to rats by whatever route (oral or im) it was given. The characteristic features of toxicity from aerial parts of R. epapposum and T. africanum were hepatonephrotoxicity, leukocytosis due to lymphocytosis or leukopenia due to neutropenia and anaemia. The anaemia was macrocytic normochromic, as indicated by the high Mean Corpuscular Volume (MCV) and normal Mean Corpuscular Hemoglobin Concentration (MCHC) values. These changes were evidenced by alterations in Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) activity and in total protein, albumin, globulin, cholesterol and urea concentrations. The occurrence of myositis brought about by the plant methanol extract given via intra muscular route probably contributed to the increase in AST activity. As conclude that the two extracts of both plant were toxic in both routs of administration and that, their toxicity result from the fact they contain chemical compound capable of damaging tissues and cells.
 
 
 
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