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Articles by Shafaq Noori
Total Records ( 2 ) for Shafaq Noori
  Shafaq Noori , Nayab Rehman , Madiha Qureshi and Tabassum Mahboob
  Cirrhosis is one of the most degenerative, world wide diseases and can be lead to an inability of liver functions. Green Tea (GT) and Coffee are natural products and considered as powerful antioxidant, chemoprotective, antiinflammatory and antitumorigenic agent. The present study was designed to investigate the protective effect of green tea and coffee against Carbon tetrachloride (CCl4)-induced liver cirrhosis by using biochemical and histopathological parameters. 24 Male Albino Wistar rats were randomly divided into 6 groups; each group consists of 4 rats. Group I comprises normal healthy rats remains untreated; Group II comprises of CCl4 (0.8 mg/kg) induced Cirrhotic rats; Group III was administered coffee orally (1 gm/100 mL) daily; Group IV administered CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 1% oral administration of coffee; Group V was administered 5% Green tea orally; Group VI comprises of CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 5% oral administration of Green Tea. The volume of green tea and coffee ingested by rats of group III and V was measured daily. The effect of antioxidants on CCl4-induced liver cirrhosis were estimated by plasma ALT, ALP, total and direct bilirubin, tissue MDA, tissue SOD, tissue catalase. CCl4-induced cirrhosis is indicated by increased level of plasma ALT, direct bilirubin, tissue MDA and decreased level of tissue SOD. Pathological changes induced by CCl4 were characterized by fibrotic scar tissue as well as regenerative nodules, the parenchyma deteriorates; the lobules are infiltrated with fat and structurally altered; dense perilobular connective tissue. Coffee and green tea reduced these changes and also restored antioxidant and liver enzymes. Our results showed the possible protective effect of coffee and green tea in association with liver and antioxidant enzymes, indicated that administration of coffee and green tea not only reversed the pathological effects of CCl4 but also counteracted on deleterious effects of CCl4- induced liver injury.
  Shafaq Noori , Humaira Zafar and Tabassum Mahboob
  Cocoa beans are main ingredient of chocolate, cakes, cookies and coffee. Cocoa have health benefits effects, previously reported. This study was designed to evaluate the health effects of cocoa powder on different biochemical parameters. For this purpose 12 Male Albino Wistar rats were divided in to 2 groups (n = 6). Group I remain healthy control rats; Group II received cocoa powder at a dose of (1 g/kg b.w.) for 21 consecutive days orally. Biochemical analysis was evaluated by electrolytes homeostasis, liver specific enzymes, kidney markers and LDH cardiac specific enzyme. The cocoa-treated rats showed decreased intra-erythrocytes potassium, increased Na+-K+-ATPase, decreased direct bilirubin, increased plasma potassium, increased ALT level. Decreased mean body weight was observed. No mortality and sign of toxicity was observed at this dose. Considerable changes were observed in biochemical parameters after chronic administration of cocoa powder.
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