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Articles by Shadman Shokravi
Total Records ( 2 ) for Shadman Shokravi
  Eshrat Gharaei-Fathabad , Mojtaba Tabatabaei Yazdi , Seyed-Naser Ostad , Shadman Shokravi , Zargham Sepehrizadeh , Mohammad Ali Faramarzi and Mohsen Amini
  A total of 100 supernatants and methanol extract samples obtained from three weeks’ incubation of 50 different isolate strains of cyanobacteria with paddy-fields origin were investigated for their cytotoxicity properties. Fifteen supernatants and 10 methanol extract samples exhibited cytotoxic activity against Balb-C cells while one methanol extract sample possessed a cytotoxic effect against five different cell lines including HeLa, Vero, Caco-2, HepG-2 and CHO more than vincristine, 5-fluorouracil and methotrexate when used at their IC50 concentrations. The later potent extract was achieved from the cyanobacterium strain GT-319. It was characterized as Nostoc piscinale Kützing ex Bornet and Flahault 1888 according to the morphological studies. Identification of the species was performed following molecular taxonomy by 16S rRNA sequencing. This is the first report on the cytotoxic activity of N. piscinale GT-319.
  Younes Ghasemi , Sara Rasoul-Amini , Mohammad Hossein Morowvat , Seyed Bagher Mosavi Azam , Shadman Shokravi , Abdolali Mohagheghzadeh , Mohammad Bagher Ghoshoon and Mohammad Javad Raee
  A unicellular microalga, Oocystis pusilla, was isolated from paddy-field and applied in the biotransformation experiment of hydrocortisone (1). This strain has not been previously tested for steroid bioconversion. Fermentation was carried out in BG-11 medium supplemented with 0.05% substrate at 25 °C for 14 days incubation. The products obtained were chromatographically purified followed by their characterization using spectroscopic methods. 11β, 17α, 20β, 21-tetrahydroxypregn-4-en-3-one (2), 11β, 17β-dihydroxyandrost-4-en-3-one (3) and 11β-hydroxyandrost-4-en-3, 17-dione (4) were the main byproducts in the hydrocortisone bioconversion. Bioreaction characteristics observed were 20-ketone reduction for accumulation of compound 2 and side chain degradation of the substrate to prepare compounds 3 and 4. Time course study showed the accumulation of the product 2 from the second day of the fermentation and 3 as well as 4 from the third day. All the metabolites reached their maximum concentration in seven days. Optimum concentration of the substrate, which gave maximum bioconversion efficiency, was 0.5 mg mL-1 in one batch. Growth was not influenced by the addition of steroid substrate. Biotransformation was completely inhibited in a concentration above 2.0 mg mL-1.
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