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Articles by Shaba Parveen
Total Records ( 2 ) for Shaba Parveen
  Ramandeep Kaur , Sidharth Mehan , Deepa Khanna , Sanjeev Kalra and Shaba Parveen
  Background and Objective: The neuroprotective ability of Ellagic Acid (EA) as a constructive herbal drug to impede cholinergic dysfunctions and oxidative stress in Alzheimer’s Disease (AD) in chronically administered scopolamine induced Alzheimer’s type dementia in rats was evaluated. Methodology: Alzheimer’s type dementia was induced by chronically administered intraperitoneal injection of scopolamine (0.7 mg kg-1) to rats for period of 7 days. The EA (25 and 50 mg kg-1) and Donepezil (0.5 mg kg-1) were administrated to rats orally daily for a period of 13 days. Memory-related behavioral parameters were evaluated using the Elevated plus Maze (EPM) for 2 days and Morris Water Maze (MWM) for 5 days. At the end of protocol schedule i.e., day 14, biochemical parameters were estimated like AChE, MDA, GSH, catalase and SOD to evaluate the neuroprotective action of EA via AChE inhibition and antioxidant activity. Result: Chronically injected scopolamine treatment increased the transfer latency in EPM, escape latency time and shortened time spent in the target quadrant in MWM; these effects were reversed by EA. Scopolamine-mediated changes in malondialdehyde (MDA) and AChE activity were significantly attenuated by EA in rats. Recovery of antioxidant capacities, including reduced glutathione (GSH) content and the activities of SOD and catalase was also evident in EA treated rats. Conclusion: The present findings sufficiently encourage that EA has a major role in the neuroprotection in chronically injected Scopolamine induced Alzheimer type dementia. The EA can be used as an effectual herbal treatment to prevent cholinergic dysfunctions and oxidative stress associated with Alzheimer type dementia.
  Alok Chattopadhyay , Ronojoy Sengupta and Shaba Parveen
  Terminalia arjuna is a well-known medicinal plant for its antidysentric, antipyretic, astringent, gastroprotective, hypocholesterolemic and cardiotonic properties. Conversely, antispermatogenic effect of this plant has also been reported. The aim of this study is to evaluate the effects of bark extract of this plant on gonadal steroidogenesis, spermatogenesis and plasma gonadotrophin (FSH and LH) levels in male albino rats. Wistar strain adult rats were administered orally with alcoholic extract of its bark dissolved in distilled water at the dose of 150 mg kg-1 day-1 for 7, 14 and 21 days. Testicular steroidogenesis was evaluated by spectrophotometric assay of the activities of 17β-hydroxysteroid dehydrogenase (17-β HSD) and Δ5-3β hydroxysteroid dehydrogenase (Δ5-3β HSD) and radioimmunoassay of plasma testosterone level. Plasma FSH and LH levels were also determined by radioimmunoassay. Spermatogenic activity was evaluated by counting the germ cells at stage VII of seminiferous cycle. Treatment for 21 days led to significant decrease in the activities of steroidogenic enzymes, plasma testosterone level and gametogenic activity. These parameters showed non-significant changes in the 7 and 14 days treatment group and no significant change was found in plasma gonadotrophin levels at any of the above durations. Though the exact mechanism of this antigonadal effect cannot be determined from the present study, one of the active constituents, β-sitosterol (a phytosterol) might be involved in this inhibition. Moreover, since treatment at the above dose and duration caused this effect, these data may have some clinical implication. Therefore, during its long-term medicinal use this adverse effect should be given due importance.
 
 
 
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