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Articles by Seyyed Mehdi Mirhashemi
Total Records ( 3 ) for Seyyed Mehdi Mirhashemi
  Seyyed Mehdi Mirhashemi , Ali-Asghar Moshtaghie , Mohsen Ani and Mohammad-Hossein Aarabi
  Alkaline phosphatase is a family of ecto-phosphomonoesterases that can be resolved into two bands on polyacrylamide gel electrophoresis, a high-molecular mass form (Mr>1 000 000) and a low molecular mass form (Mr: 150000). The relationship between aluminium treatment and changes in the activity of serum, liver and brain high and low molecular weight alkaline phosphatase has been investigated in this manuscript. Results obtained from in vivo study showed that every other day intrapritoneally injection of 186 μmol kg-1 of aluminium (AlCl3.6H2O), in male rats for 2 weeks resulted in decreasing the level of liver and brain alkaline phosphatase by 14.9 and 9.9%, respectively, whereas an elevation of serum levels of this enzyme by 21.1% was seen in comparison to untreated controls (p<0.05). Long-term exposure of 74.5 μmol kg-1 of this salt, showed a statistically significant reduction in liver and brain level of alkaline phosphatase by 15.8 and 12.3%, respectively and an increment in serum activity of the enzyme by 30.9% in compared to control group (p<0.05). Gel filtration chromatography technique with sephacryl S300 showed that, in comparison to control groups, serum and liver homogenates from aluminium treated groups had a significant level of high molecular weight alkaline phosphatase. In vitro experiments showed that aluminium inhibited all the isoenzymes non-competitively. Low molecular weight alkaline phosphatases were more heat and urea stable than high molecular weight fractions.
  Hamidreza Javadi , Hayedeh Yaghoobzadeh , Zohreh Esfahani , Mohammad Reza Memarzadeh and Seyyed Mehdi Mirhashemi
  Background and Objective: Hypertension is a long-term medical condition in which the blood pressure is gradually elevated. In this project, the effects of olive leaf extract (OLE) were evaluated on metabolic response, liver and kidney functions and also biomarkers of inflammation in hypertensive patients. Materials and Methods: In this randomized double-blind placebo controlled clinical trial, 60 hypertensive patients, aged 30-60 years old had participated. Patients were randomly assigned into two groups to receive either OLE or placebo tablets for 12 weeks. At the beginning and end of the intervention, metabolic parameters and biomarkers of liver, kidney and inflammation were measured in sera of the participants using available laboratory methods. Results: Compared with the placebo, changes in parameters associated with glucose metabolism were not statistically significant (p>0.05). The OLE tablets did not have significant effect on liver enzymes, total protein, albumin, urea and creatinine (p>0.05), but significantly decreased interleukin-6, interleukin-8 and tumor necrosis factor alpha as inflammatory biomarkers (p<0.05) in OLE group compared to the placebo group. Conclusion: The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using OLE tablets.
  Ali Akbar Karami , Mahsa Sheikhsoleimani , Mohammad Reza Memarzadeh , Elnaz Haddadi , Mohammad Bakhshpour , Navid Mohammadi and Seyyed Mehdi Mirhashemi
  Background and Objectives: Benign Prostatic Hyperplasia (BPH) is a common urological disorder as men get older. BPH can cause uncomfortable urinary tract symptoms. Given the high incidence of the disease, further research is an undeniable necessity for its better management. In this research, the efficacy of Urtica Dioica root extract (UDE) on clinical and biochemical parameters were evaluated in this type of patients. Materials and Methods: Participants were 60 men with BPH that randomly allocated to two equal groups (Intervention = 30 and Comparison = 30). Block balanced Randomization method was performed using a computer by a trained nurse. Intervention and comparison groups received 450 mg day1 UDE and placebo as tablets for 12 weeks, respectively. The main outcome was changes in International Prostate Symptoms Score (IPSS) from baseline to end of treatment. Data were collected by completing a standard questionnaire and performing relevant tests based on common laboratory methods. Results: UDE had an intermediate effect on IPSS, a small effect on serum high-sensitivity C-reactive protein (hs-CRP), intermediate to large effect on malondialdehyde (MDA) levels and intermediate effect on superoxide dismutase (SOD) activity. The magnitude of the effects of UDE on other parameters was overall negligible compared to the comparison and not significant. No side effects were seen in these patients following tablet usage. Conclusion: UDE consumption for 12 weeks among BPH patients had clinically significant effects on IPSS, serum hs-CRP, MDA and SOD activity.
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