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Articles by Seyed Nasser Ostad
Total Records ( 2 ) for Seyed Nasser Ostad
  Mahnaz Khanavi , Shabnam Pourmoslemi , Behnaz Farahanikia , Abbas Hadjiakhoondi and Seyed Nasser Ostad
  Vinca minor L. (Apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in European folk medicine. Furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in Catharanthus roseus (L.) G. Don (Apocynaceae). In this study, the plant’s alkaloid extract was divided into three fractions and the cytotoxic effects on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines were examined. All alkaloid fractions showed a dose-dependent cytotoxic effect on the cell lines. IC50 values confirmed that the growth and proliferation of NIH/3T3 cells were less affected in comparison to other cell lines.
  Mahnaz Khanavi , Mana Moshteh , Azadeh Manayi , Mohamad Reza Shams Ardekani , Mahdi Vazirian , Yousef Ajani and Seyed Nasser Ostad
  The aerial parts of Lythrum salicaria L. from Lahijan in Gillan province have been collected in June 2009. Total extract were obtained by MeOH/H2O (80/20) and then partitioned between CHCl3, EtOAc and MeOH. These fractions and total extract have been investigated for in vitro cytotoxic activity against colon carcinoma (HT-29), lukemia (K562), breast ductal carcinoma (T47D) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT assay (3-(4,5-di methyl thiazol-2-yl)-2,5-di phenyltetrazolium bromide). At each cell line doses of 50, 100, 200, 400 and 800 μg mL-1 in 1% (v/v) DMSO of all samples were tested. Ethyl acetate fraction against proliferation of T47D cell line has been represented high cytotoxic activity (IC50<70). Chloroform fraction and total extract against proliferation of T47D cell line and chloroform fraction toward K562 cell line and total extract against HT-29 cell line have been demonstrated slightly cytotoxic activity (IC50<200). The other fractions have been demonstrated no effective cytotoxic activity. IC50 values confirmed that the growth and proliferation of T47D cells were most affected by ethyl acetate fraction.
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