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Articles by Settu Dinesh Kumar
Total Records ( 1 ) for Settu Dinesh Kumar
  Settu Dinesh Kumar , Muhasaparur Ganesan Rajanandh and Chamundeeswari Duraipandian
  Background and Objective: Management of anxiety with synthetic drugs result in diverse systemic side effects. Traditional plant and herbal remedies available come into the limelight for their effective and safe use in anxiety. The present study investigated the acute and sub-acute toxicity studies of a polyherbal combination (PHC), namely PHC3 for the management of anxiety. Materials and Methods: The prepared PHC contains the roots of Withania somnifera (Ashwagandha), Hemidesmus indicus, fruit of Aegle marmelos (Bael), pericarp of Emblica officinalis (Amla) and fresh juice of aerial parts of Ocimum sanctum (Tulsi) in selected ratio. Acute, sub-acute toxicity studies and histopathological study were carried out as per the standard guidelines. Results: No mortality was observed in acute toxicity study. In sub-acute toxicity study, no statistically significant (p>0.05) difference was observed with respect to feed intake, water intake, body weight changes, biochemical enzymes, biochemical metabolites, electrolytes, hematology and histopathology studies between control and treated rats. Conclusion: The developed polyherbal combination was found to be safe in both acute and sub-acute toxicity studies and thus, the tested combination is suitable for further pharmacological and pharmacokinetic studies.
 
 
 
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