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Articles by Sepideh Arbabi Bidgoli
Total Records ( 2 ) for Sepideh Arbabi Bidgoli
  Sepideh Arbabi Bidgoli , Bagher Minaee , Mansoor Djamali Zavarehi , Shamileh Fouladdel and Ebrahim Azizi
  Comparative study of markers of drug resistance in cancer tissues may be extremely helpful in selection of effective chemotherapeutic regimen. P-glycoprotein (P-gp) and Topoisomerase II α (Topo II α) are two fundamental proteins in multi-drug resistance phenomenon (MDR). This study determined the expression and significance of P-gp and Topo II α proteins in advanced gastric carcinomas and correlated molecular alterations with clinicopathological findings. Tissue samples of 35 patients with advanced type gastric adenocarcinoma were analyzed. Immunohistochemical techniques were applied using primary antibodies for P-gp or Topo II α and LSAB2 detection kit (Dako-Denmark). Positive immunostaining for P-gp and Topo II α were observed in 42.9% and 17.2% of tumor samples, respectively. Negative expressions of P-gp and TopoII were associated with sex (p = 0.035 and 0.0001) and histological grade (p = 0.021 and 0.0001), respectively. Unlike P-gp, an inverse relationship between Topo II α expression and size of tumors (p = 0.012) and lymphatic invasion (p = 0.013) were observed. Considering the key role of positive P-gp or negative Topo II α expression in MDR, it could be concluded that groups of patients with P-gp over expression (42.9%) or lack of Topo II α expression (82.8%) would less likely benefit from available chemotherapeutic regimens. Therefore, we highly recommend determination of tumor status for expression of tumor markers such as P-gp and Topo II α, before deciding about effective chemotherapeutic regimen for patients with gastric cancer.
  Mansoor Djamali Zavarhei , Sepideh Arbabi Bidgoli , Mehri Mohammadi Ziyarani , Marjan Shariatpanahi and Farid Azmoodeh Ardalan
  Present study aimed to find the clinicopathological significance of PgR and its association with TP expression in colorectal cancer. Immunohistochemical studies were performed on 83 colorectal adenocarcinoma patients using corresponding monoclonal antibodies of PgR and TP and LSAB detection kit. Mucin producing cells showed PgR expression and its expression was detected in 15.6% of normal and 59% of malignant tissues. Significant association were observed between PgR negative expression in malignant tissues and larger tumor size (p = 0.006), higher incidence of secondary organ metastasis (p = 0.014) and tumor pathological stage (p = 0.041). A close association was observed between PgR and lack of TP expression in malignant tissues that means out of 49 PgR (+) tumors, 43 cases (86%) were TP negative (p = 0.046). It seems that tumors with better prognosis were more likely to express PgR in their malignant tissues, which affects the expression of TP as one of the major therapeutic targets in CRC. Present study suggests progesterone therapy as a possible effective strategy to suppress colorectal cancers and as a novel anti-angiogenic therapy for tumor dormancy which needs complimentary studies for confirmation.
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