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Articles by Satish Kumar
Total Records ( 6 ) for Satish Kumar
  Vijay Kumar Saxena , Sameer Srivastava , Satish Kumar and S.M.K. Naqvi
  Kisspeptin, also called as metastin, is the cognate ligand GPR-54 (G-coupled receptor) which was previously an orphan receptor. Kisspeptin consists of 145 amino acids and its biological activity can be localized to the C-terminal segment which is cleaved into C-10, C-13 and C-14 segment. Kisspeptin-GPR-54 interaction stimulates GnRH secretion and has been shown to be essential for the initiation of the pubertal LH surge. A 13 amino acid derivative of kisspeptin was synthesized by solid phase peptide synthesis using F-moc strategy and it was purified using RP-HPLC. The CD spectra of the peptide (1 mg mL-1) was evaluated in water, 50% and 75% TFE. The CD spectra of kisspeptin 13 in the water mainly exhibited random coil structure with no significant alpha helical or beta sheet content. Increasing concentration of TFE could cause slight induction of both beta sheet and alpha helix structures but still disordered random coil being the major contributor to the conformation. Predominantly disordered structure of kisspeptin 13 as elucidated by the experiment may explain its multifunctional role and non putative receptor binding and may help to develop a few agonists for mimicking the therapeutic action for future drug use.
  Satish Kumar and Arun Choudhary
  In this study, a new measure, Lβα called average code word length of order α for incomplete power probability distribution pβ has been defined and its relationship with a result of generalized Renyi's entropy has been discussed. Using Lβα , a coding theorem for discrete noiseless channel has been proved.
  Satish Kumar and Arun Choudhary
  In this study, we study one parametric generalization measure of H (P) and H (P; Q). For the measure H (P; Q) we give three different kind of generalizations. These generalizations are R-Norm entropy and R-Norm inaccuracies. The Shannon-Gibbs type inequality has been generalized in different way using Holder’s inequality for R-Norm information measure and three different kinds of inaccuracy.
  V. M. Vaidya , S. V. S. Malik , Simranpreet Kaur , Satish Kumar and S. B. Barbuddhe
  Coxiella burnetii, an obligate intracellular parasite with a worldwide distribution, is the causative agent of Q fever in humans. We tested a total of 368 samples (placental bits, genital swabs, fecal swabs, and urine and serum samples) collected from women (n = 74) with spontaneous abortions for C. burnetii by a PCR assay targeting IS1111, the repetitive transposon-like region of C. burnetii (trans-PCR); real-time PCR; an indirect immunofluorescence assay (IFA); and the isolation of the pathogen. The IFA showed seropositivity for 25.68% of the women with spontaneous abortions, whereas trans-PCR and real-time PCR each detected the pathogen in 21.62% of cases. Overall, 25.68% of the subjects were positive by one or more assays. Real-time PCR showed a slightly higher level of sensitivity than trans-PCR. With the IFA as the reference, the two PCR assays showed a higher level of sensitivity (84.21%) than pathogen isolation (26.31%), while both the PCR assays and pathogen isolation were specific (100%). The detection of high numbers of C. burnetii cells in clinical samples and the frequent association of the pathogen with cases of spontaneous abortions observed in this study revealed that Q fever remains underdiagnosed and that the prevalence in India is underestimated.
  Satish Kumar and Arun Choudhary
  In the present communication, a new generalized parametric R-norm information measure has been defined and its properties, as well as an axiomatic characterization, are given. The measure is extended to conditional and joint measures.
  Mrigakshi Yadav , S.K. Rastogi , Satish Kumar and Malini Pant
  Monitoring anaesthetic depth allows recognizing the extent of physiological stress. Heart is the core organ directly influenced by stress while hematological and biochemical analysis allow quick and accurate diagnosis. This study aimed to evaluate stress on goats subjected to propofol and xylazine-ketamine anaesthesia electrocardiographically, hematologicaly, biochemicaly and by clinical parameters thereby suggesting a suitable anaesthetic for short term surgical interventions. Twelve healthy adult female crossbred goats, aged 2-4 years were randomly allocated to two groups according to the anaesthetics. Electrocardiography (ECG), Oxyhemoglobin (HbO2) saturation, Hematological (Hb concentration, PCV, TEC, TLC, DLC, MCV, MCH and MCHC), blood glucose and clinical parameters (rectal temperature, pulse and respiratory rates) were assessed. The results indicated that after propofol and xylazine-ketamine administration HbO2 decreased (within normal physiological limits after xylazine-ketamine administration), all ECG parameters increased except QRS interval (no change). During propofol anaesthesia rectal temperature, respiratory rate and hematological parameters (except lymphocyte count) decreased while blood glucose concentration and pulse rate increased. During xylazine-ketamine anaesthesia, similar observations were recorded except that pulse rate decreased and MCHC non-significantly increased. Propofol produced favorable effects on cardiovascular system, rectal temperature and pulse rate whereas, xylazine-ketamine exerted more effective anaesthetic effects on respiratory system, blood glucose concentration and hematology suggesting it to be a safer and better choice over propofol for short period anaesthetic requirements in goats. Therefore, it could be suggested for further investigations in clinical conditions.
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