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Articles by Sathyapriya Kandavelu
Total Records ( 2 ) for Sathyapriya Kandavelu
  Sathyapriya Kandavelu and Parameswari Chetenchery Somasundaram
  Many End staged Renal Diseased and hemodialysis patients are in a state of chronic inflammation induced by the dialysis process which further enhances oxidative stress. The study aim was to explore the critical role of Heme oxygenase-1, a potent antioxidant, in patients subjected to various dialysis conditions. The study population contained randomly selected end-staged renal failure patients (n = 64) who have been treated by hemodialysis for at least 6 months, between the age group of 20-50 with creatinine levels greater than 5 mg dL-1. About 20 samples were collected from predialysis patients, 22 samples were collected from patients undergoing dialysis and 22 samples were collected from post dialysis patients. The samples were subjected to antioxidant enzyme analysis followed by flow cytometric and immunoflouroscence studies HO-1 expression was found to be elevated in all the dialysis conditions but higher elevation was observed in post dialysis patients. The results suggest that HO-1 might have some link with the disease progression and though upregulated like other stress proteins, it’s antioxidant capacity has been ineffective to cease the disease invasion.
  Sathyapriya Kandavelu and A.J. Vanisree
  Malignant gliomas, the most common subtype of primary brain tumors, are aggressive, highly invasive and neurologically destructive tumors, considered being the deadliest of human cancers. As an attempt to understand the biology of glial tumor, a study on macromolecules like proteins, matrix metalloproteinases, lipids antioxidants and Deoxyribonucleic acid, in the blood of glioma patients was made. Biochemical assessment of significant pathophysiological enzymes, antioxidants and marker enzymes was performed. MMP expression was determined using gelatin zymography. Karyotyping analysis was done to determine chromosomal aberrations. A marked rise was observed in the proteins and lipids of glioma patients as compared to the normal cases. The antioxidant status of the patients was found to be lowered. Karyotypic analysis of the peripheral blood chromosomes presented various chromosomal aberrations in glioma patients. The biochemical parameters were significantly increased in the patient population (p<0.01, p<0.001) when compared to those of normal. Zymographic analysis showed the presence of MMP-2 and MMP-9 in the patient sample. Karyotypic investigation showed alterations in the chromosomal pattern of the glioma patients. The study provides baseline information on the biochemical alterations in the blood of glioma patients which can be further exploited for detailed investigations.
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