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Articles by Sarita Sharma
Total Records ( 1 ) for Sarita Sharma
  Narinder Pal Singh , Rajesh Kumar , Deo Nandan Prasad , Sarita Sharma and Om Silakari
  The aim of present study was to carry out the synthesis of benzotriazole substituted acridine derivatives and to evaluate their antibacterial activity. The 9-chloroacridine derivatives 1a-b was treated with o-phenylenediamine in presence of methanol to obtain 9-substituted acridine derivatives 2a-b. These were finally cyclized to get benzotriazole substituted acridine derivatives 3a-b. The synthesized compounds were then established on the basis of IR and 1H NMR spectra data and screened for antibacterial activity. Successfully synthesized four acridine derivatives. Out of these, two compounds 2a and 2b showed moderate activity while two compounds 3a and 3b showed good antibacterial activity. The derivatives with free amine group 2a-b were less prone towards antibacterial activity as compared to derivatives lacking the free amine group 3a-b.
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