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Articles by Saraf Shailendra
Total Records ( 2 ) for Saraf Shailendra
  M.S. Ashawat , Saraf Shailendra and Saraf Swarnlata
  The present investigation deals with antioxidant activities of the ethanolic extract of C. asiatica fresh leaves, P. granatum seeds, G. glabra dry root and A. catechu nuts. The effects of all ethanolic extracts of the herbs were studied via reducing power estimation method. The antioxidant activities of the extracts were compared with standard i.e., of ascorbic acid. The equal amount of extract and ascorbic acid combination antioxidant activity was also studied to know the synergistic effect of chemical and extract in any pharmaceutical and cosmetic formulations. The individual antioxidant activity of C. asiatica, P. granatum, G. glabra and A. catechu were found to be 8.23±0.12, 24.35±0.25, 24.25±0.52, 31.31±1.80%, respectively to the standard indicating antioxidant activity to all ethanolic extracts, but catechu showed highest activity (p<0.05). The combined antioxidant activity (ascorbic acid with extracts) showed additive synergistic effect as compared to standard i.e., 110.51±0.422, 127.51±0.745, 128.09±0.235, 134.73±0.60, respectively with each extract. These studies may suggest that the combination of chemical with extract as antioxidant can be utilized in pharmaceutical and cosmetic formulation or chemical antioxidant replaced by herbal natural antioxidants.
  M.S. Ashawat , Saraf Shailendra and Saraf Swarnlata
  The present study was to prepare and characterized herbal cosmetic cream comprising extracts of G. glabra, C. longa (roots), seeds of P. corlifolia, C. tora, A. catechu, P. granatum, fruits of E. officinale, leaves of C. asiatica, dried bark of C. zeylanicum and fresh gel of A. vera for the protection of skin against UV induced aging. To investigate the antioxidant activity of cream formulations the UV radiation induced oxidative stress was generated in rats and protective effects were measured after topically applied (2 mg cm-2 day-1) for thirty days. The level of antioxidant enzymes (catalase and superoxidedismutase), non-enzyme components (ascorbic acid level and melanodialdehyde) and ascorbic acid were estimated. The structural changes were observed by using histological techniques. Results showed significant improvement in superoxidedismutase, catalase, total protein and ascorbic acid level with decreased melanodialdehyde level. The treatment with such herbal extracts containing creams could be utilized for the protection of photo induced intrinsic oxidative stress as well as structural alterations in skin.
 
 
 
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