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Articles by Sanjeev Kalra
Total Records ( 2 ) for Sanjeev Kalra
  Navdeep Bansal , Sidharth Mehan , Sanjeev Kalra and Deepa Khanna
  Traditionally, herbal plants are widely and frequently used as medicines for curing and anticipating of various diseases and ailments. Plants belonging to family Burseraceae are very important and widely used as therapeutic agents. From ancient times, Boswellia serrata (BS), belonging to family Burseraceae is well known as frankincense (Jesus gifted herb). Resins are main constituents of Burseraceae family, β-boswellic acid, acteyl-β-boswellic acid, 11-keto-β-boswellic acid, acetyl-11-keto-β-boswellic acid, α-boswellic acid, acetyl-α-boswellic acid are few among several medicinally important constituents of BS generally used for curing various ailments such as rheumatism, skin diseases, cough, diarrhea, constipation, flatulence, stomachic, carminative, diuretic and neurodegenerative. Bench work has revealed numerous pharmacological activities of BS viz., anti-inflammatory, anti-oxidant, anti-ulcer, anti-arthritic, anti-asthmatic, anti-artherosclerotic, anti-cancer, anti-diarrhoeal, hepatoprotective, anti-microbial, anti-hyperglycemic, wound healing, diuretic and analgesic. However, few activities like wound healing, hypoglycemic property need intense and focused research for confirmed results. In this review, we have widely discussed chemical constituents and medicinal potential of BS.
  Ramandeep Kaur , Sidharth Mehan , Deepa Khanna , Sanjeev Kalra and Shaba Parveen
  Background and Objective: The neuroprotective ability of Ellagic Acid (EA) as a constructive herbal drug to impede cholinergic dysfunctions and oxidative stress in Alzheimer’s Disease (AD) in chronically administered scopolamine induced Alzheimer’s type dementia in rats was evaluated. Methodology: Alzheimer’s type dementia was induced by chronically administered intraperitoneal injection of scopolamine (0.7 mg kg-1) to rats for period of 7 days. The EA (25 and 50 mg kg-1) and Donepezil (0.5 mg kg-1) were administrated to rats orally daily for a period of 13 days. Memory-related behavioral parameters were evaluated using the Elevated plus Maze (EPM) for 2 days and Morris Water Maze (MWM) for 5 days. At the end of protocol schedule i.e., day 14, biochemical parameters were estimated like AChE, MDA, GSH, catalase and SOD to evaluate the neuroprotective action of EA via AChE inhibition and antioxidant activity. Result: Chronically injected scopolamine treatment increased the transfer latency in EPM, escape latency time and shortened time spent in the target quadrant in MWM; these effects were reversed by EA. Scopolamine-mediated changes in malondialdehyde (MDA) and AChE activity were significantly attenuated by EA in rats. Recovery of antioxidant capacities, including reduced glutathione (GSH) content and the activities of SOD and catalase was also evident in EA treated rats. Conclusion: The present findings sufficiently encourage that EA has a major role in the neuroprotection in chronically injected Scopolamine induced Alzheimer type dementia. The EA can be used as an effectual herbal treatment to prevent cholinergic dysfunctions and oxidative stress associated with Alzheimer type dementia.
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