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Articles by Sanjar Alam
Total Records ( 1 ) for Sanjar Alam
  K.M. Nidhi , Sanjar Alam , Yatendra Kumar , Anil Kumar , K.M. Uma and Naveen Sharma
  Cimetidine is histamine (H2 blocker). It is used in the treatment of ulcer, acid-peptic disease and heartburn. It is also known as an H2-receptor antagonist who is responsible for inhibiting acid development in the stomach. The Aim and objective of this work was to build up a gastro retentive drug delivery system. The cimetidine used as a model drug for making mucoadhesive dosage form. This formulation can be achieved by using ionic gelation method. The model drug used in this work plan is categorized in the treatment of antiulcer. The extended-release mucoadhesive microspheres of model drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of model drug using Sodium alginate and Carbopol 934 used as an excellent mucoadhesive agent which can adhere on the gastrointestinal membrane for sustained drug delivery in the stomach. The calcium chloride was also used for making solvent system and to evaluate the model drug mucoadhesive microspheres in-vitro for their drug release pattern FTIR, SEM and DSC curve. The mucoadhesive microspheres were prepared by ionic gelation method by using polymers like carbopol 934 used as mucoadhesive polymer and sodium alginate as rate controlling polymer. Preformulation study shows no interaction between drug and excipients. The prepared mucoadhesive microspheres of cimetidine shows particle size of between 167.14-218.23 μm. Entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after 7 h of F6 formulation show good release was 85.60%. The surface morphology using SEM of prepared microspheres reveals very smooth surface with spherical shape. All prepared formulations exhibits good percentage yield and drug release rate. As the amount of sodium alginates and calcium chloride was increased it reduces percentage drug release. The increased amount of polymer was raised significantly the particle size of microspheres. In-vitro drug release studies were used for indicating that there was a controlled and prolong release of drug in the stomach and intestine. So, we can say the formulation F6 was better candidate of all the developed formulations.
 
 
 
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