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Articles by Sanaa Botros
Total Records ( 2 ) for Sanaa Botros
  Sanaa Botros , Sayed Seif el-Din , Naglaa El-Lakkany , Abdel Nasser Sabra and Fatma Ebeid
  The level of drug metabolizing enzymes (CYP450 and cyt b5) and the bioavailability of praziquantel (PZQ) were investigated in batches of mice infected with Schistosoma mansoni (S. mansoni) displaying either a decreased susceptibility to PZQ (EE2 and BANL-isolates), or a normal susceptibility to the drug (CD isolate). Each batch was divided into two groups. The first one comprising 50 animals was further subdivided into 5 subgroups. Subgroups 1 to 4 were treated with oral PZQ at 25, 50, 100 and 200 mg kg 1 for 5 consecutive days beginning on the 7th week after infection, while the fifth subgroup was administered the vehicle only as a control. Animals were perfused 9 weeks post infection, and worms were counted to estimate PZQ ED50. CYP450 and cyt b5 were examined in hepatic microsomes of infected untreated mice and of infected mice treated with 25 mg kg 1 and 200 mg kg 1 PZQ. The second group comprising 77 animals was given PZQ 7 weeks post infection and was further subdivided into 11 subgroups, sacrificed at 2, 5, 15, 30, 60, 90, 120,150, 180, 240 and 360 minutes post dosing to study pharmacokinetic parameters of PZQ. Mice harboring S. mansoni isolates having higher PZQ ED50 (170.3 mg kg 1 for EE2 and 249.9 mg kg 1 for BANL vs 82.96 mg kg 1 for CD) had higher levels of CYP450 and cyt b5, a PZQ Cmax decreased by 19-30% and AUC0-6hr decreased by 57-74%. Data may suggest that S. mansoni isolates that are less sensitive to PZQ induce a lower inhibition of hepatic drug metabolizing enzymes, with a consequently higher metabolic transformation of PZQ.
  Sanaa Botros , Rania Abdel-Kader , Maged El-Ghannam , Ahmed El-Ray , Samira Saleh and Madiha Mahmoud
  This study investigates the effect of dimethyl diphenyl bicarboxylate, which is widely used in Egypt, as a treatment for hepatitis C patients on the metabolic or biochemical liver function, using antipyrine clearance test and conventional liver function tests. All subjects ingested 600 mg antipyrine after overnight fasting. One milliliter saliva was collected and pharmacokinetic values were examined using high performance liquid chromatography according to first kinetic order. Blood samples were collected for examination of conventional liver function tests. All parameters were examined at the onset of the study and at 2, 6 and 12 weeks post dimethyl diphenyl bicarboxylate treatment. Thirty three hepatitis C patients complying to treatment follow-up protocol were compared to 15 healthy volunteers. Child-Pugh class B and C patients did not show any improvement in either antipyrine clearance or biological parameters, yet they were limited in number. Child- Pugh class A comprising 20 patients still did not show any improvement in antipyrine clearance, aspartate aminotransferase and gamma-glutamyl transferase, apart from significant improvement in alanine aminotransferase. Therefore, it can be concluded that dimethyl diphenyl bicarboxylate did not improve the metabolic or biochemical liver function that was impaired due to hepatitis C virus infection.
 
 
 
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