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Articles by Sami Ghazal
Total Records ( 1 ) for Sami Ghazal
  Sami Ghazal , Soleymanian Tayebeh , Khoshraftar Ebrahim and Ranjbar Akram
  Background and Objective: Cisplatin is a widely used chemotherapeutic agent to treat solid tumors. The aim of this study is to evaluate the effects of propofol as a antioxidant on the level of liver enzymes (ALT and AST) in plasma and oxidative damages in liver tissue in rats induced by cisplatin. Methodology: In this study 20 male Wistar rats were at random separated to four groups (n = 4) and then, treated intraperitoneally (IP) for one week. The groups were as follows: Propofol group, control group, cisplatin group, propofol and cisplatin group. Then, propofol was administered (10 mg kg–1 day–1, IP) alone or in mixture with cisplatin (7 mg kg–1 day–1, IP). Also, control group received only normal saline. Oxidative stress parameters, such as: Total Antioxidant Capacity (TAC), catalase (CAT) and total thiol molecules (TTG) in liver tissue and the levels of ALT and AST in serum were measured. Results: Cisplatin hepatotoxicity was manifested by an increase in serum ALT and AST and decrease in TAC in liver tissues. Serum ALT was found to decreased significantly (p<0.008) in the combination group (propofol+cisplatin) in comparison with the cisplatin group. Conclusion: In conclusion, the present results suggest that propofol decrease liver injury induced by cisplatin treatment in liver rats. Further study is needed to clarify the pharmacological significance of its effects on cisplatin poisoning.
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