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Articles by Sameer H. Sawant
Total Records ( 1 ) for Sameer H. Sawant
  Sameer H. Sawant and Subhash L. Bodhankar
  Background: Recently the antihyperlipidemic, cardioprotective and in vitro antioxidant activity of Flax Lignan Concentrate (FLC) obtained from Linum usitatissimum Linn. (Linaceae) has been reported. The present study was aimed to assess the antihypertensive effect of FLC in L-NAME-induced hypertensive rats. Materials and Methods: Wistar rats (200-240 g) were given L-NAME (40 mg kg–1 b.wt. day–1, p.o.) in drinking water for 4 weeks to induce hypertension. Rats were randomly divided into six groups: Control, L-NAME control, captopril (30 mg kg–1, p.o.) and FLC (200, 400 and 800 mg kg–1, p.o.). The FLC and standard drug captopril (30 mg kg–1) were also administered daily for 4 weeks. Result: The FLC (400 and 800 mg kg–1) significantly (p<0.01 and p<0.001) and dose-dependently decreased the elevated Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Blood Pressure (MABP). It also normalized the altered left ventricular End Diastolic Pressure (EDP), dP/dt max. and dP/dt min. It also prevented the increase in heart weight and a decrease in heart rate and body weight. Undesirable changes, such as increased malondialdehyde (MDA) level and decreased the concentration of enzymatic antioxidants superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione (GSH) in the tissues (heart and aorta) were rectified after the administration of FLC (400 and 800 mg kg–1). Oral administration of FLC (400 and 800 mg kg–1) decreased Angiotensin Converting Enzyme (ACE) and also prevented the decrease in nitrite and nitrate concentration and cyclic guanosine monophosphate (cGMP) levels in plasma and tissues (heart and aorta). Conclusion: These finding suggested that the antihypertensive property of FLC in L-NAME hypertensive rats may be because of increased bioavailability of NO, ACE inhibition and antioxidant nature.
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