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Articles by Salvatore Musumeci
Total Records ( 2 ) for Salvatore Musumeci
  Cecilia Zuppi , Jacques Simpore , Bruno Zappacosta , Cinzia Carrozza , Mariano Malaguarnera and Salvatore Musumeci
  Biological aging implies a progressive decrease of endocrine and metabolic resources, which correspond to a reduction of working activity and caloric intake. The aim of this study was to measure DHEA-S and IGF-1 and products of methionine metabolism in 76 postmenopausal African women (50 to 100 years of age) compared to 22 adult African fertile women (30 to 45 years of age). Determination of plasma DHEA-S in elderly women gave a markedly low mean concentration and the same was observed for plasma IGF-1 (450.1±263.2 and 64.2±38.1 ng mL-1, respectively). The correlation between DHEA-S and IGF-1 was significantly positive only in 71-100 years women (r = 0.44, p<0.05). There was a significant decrease of plasma glutathione in all elderly women (3.5±0.4 μMol L-1), while the plasma homocysteine (Hcy) was markedly elevated (18.7±0.5 μMol L-1), whilst that of folic acid, Vit B12 and Vit B 6 levels were found in the normal range. A significant positive correlation between DHEA-S and plasma glutathione levels (r = 0.56, p<0.025) was found only in the 50-60 old years women group, while the correlation between IGF-1 and plasma glutathione was negative but not significant (r = -0.36, p = NS) in the same age group. In this study a low level of IGF-1 and DHEA-S in old humans is firstly considered as consequence of hypo-caloric alimentation, moderate physical activity and absence of psychophysics stress. Moreover a positive correlation between IGF-1 and DHEA-S in oldest age populations, ranging from 71 to 100 years, suggests that endocrine and metabolic systems must be maintained in a lower equilibrium to compensate the physiological reduction of the oxidant/antioxidant balance (low level of plasma glutathione).
  Jacques Simpore , Frederic Zongo , Youssouf Ouattara , Fatoumata Kabore , Deleli Dansou , Augustin Bere , Jean-Baptiste Nikiema and Salvatore Musumeci
  The objective of the study was to assess the impact of an alimentary integrator composed by Spiruline (Spirulina platensis), produced at the Centre Medical St Camille (CMSC) of Ouagadougou, Burkina Faso, on the nutritional status of undernourished HIV-infected and HIV negative children. We compared two groups of children: 84 children HIV-infected and 86 HIV-negative. The duration of this study was eight weeks. Anthropometrics and haematological parameters allowed us to appreciate both the nutritional and biological effects of Spiruline supplement to traditional meals. The rehabilitation with Spiruline shows on average a weight gain of 15 and 25 g/day in HIV-infected and in HIV negative children, respectively. The level of anaemia decreased during the study in all the children, but the recuperation was less efficient among the HIV-infected children, in fact, 81.8% of HIV negative undernourished children recuperated against 63.6% of HIV-infected children [Z: 1.70 (95% CI: -0.366, -0.002, p=0.088)]. Present results allow to confirm that Spiruline is a good food supplement for undernourished children. In particular the rehabilitation by Spiruline seems to correct the anaemia and the weight loss also in HIV-infected, but more quickly in HIV negative undernourished children.
 
 
 
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