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Articles by Salih CESUR
Total Records ( 2 ) for Salih CESUR
  Hulya SIMSEK , Sibel Meryem ALPAR , Kurtulus AKSU , Funda AKSU , Ismail CEYHAN , Salih CESUR , Aysegul GOZALAN and Mustafa ERTEK
  Until recently, the tuberculin skin test (TST) has been the only assay used for detecting latent tuberculosis infection (LTBI), but two ex-vivo tests, used as alternative methods to TST, based on enumerating the M. tuberculosis-specific interferon (IFN)-γ response are now commercially licensed. The aim of this study was to compare the sensitivity and specificity of TST, QuantiFERON Gold (QFT-G), and T-SPOT.TB in diagnosing LTBI and active tuberculosis (TB). Materials and methods: This study was carried out with 95 participants including 3 groups (negative control, close contact, and patient groups) during a 10-month period from March 2007 to January 2008. Results: When the cut-off value of the TST was regarded as >=15 mm, 46.4% of the patients and 14.3% of the control group were found to have positive values. The sensitivity (51.4%) and the negative predictive value (NPV) (52.6%) of TST were lower than the specificity (83.3%) and the positive predictive values (PPV) (82.6%). The sensitivity and the PPV of the QFT-G test (78.4% and 76.3%, respectively) were higher than the specificity (62.5%) and NPV (65.2%). The PPV (81.8%) of the T- SPOT.TB test was higher than sensitivity (73.0%), specificity (75.0%), and NPV (64.3%). Conclusion: IFN-γ tests could be useful in diagnosing LTBI and chemo-prophylaxis, as the false negativity of the TST was higher compared to both QFT-G and T-SPOT.TB. However, additional studies are needed to assess better the utility of these tests with large populations.
  Zeliha KOCAK TUFAN , Selcan ARSLAN , Salih CESUR , Cemal BULUT , Hasan IRMAK , Sami KINIKLI , Ferah ERGIN , Ali Kutta CELIK and Ali Pekcan DEMIROZ
  The resistant organisms from patients and healthcare workers (HCWs) first colonized the gastrointestinal tract before causing infections in patients. In this study, presence of risk factors for vancomycin-resistant enterococci (VRE) colonization and the prevalence of rectal carriage of VRE among HCWs and hospitalized patients in the absence of an outbreak were investigated. Design: Cross-sectional study. Setting: A 600-bed training and research hospital. Materials and methods: A total of 508 intensive-care unit (ICU) patients and HCWs in these units were included. Risk factors such as previous antibiotic use, especially vancomycin and cephalosporin, the presence of invasive devices like catheters, and co-morbid diseases were investigated. Rectal smear cultures were obtained from each participant to detect VRE colonization. Results: Risk factors for VRE colonization were identified among both patients and HCWs with a significant ratio. Except for one patient, who had been transferred from another hospital, no VRE colonization was detected in patients or HCWs. Conclusion: The result was attributed to factors such as low inter-institutional transfer, HCWs' being free of VRE colonization (transmission is less likely), strict infection control strategy of the hospital, isolation of newly transferred patients suspected of having VRE colonization, isolation of VRE colonization identified patients, use of indwelling catheters only when indicated and their early removal, and low prevalence of predisposing co-morbid diseases and malignity. We want to underline that a strict hospital infection control program can prevent colonization, even in the presence of risk factors.
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