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Articles by Saleh I. Alqasoumi
Total Records ( 4 ) for Saleh I. Alqasoumi
  Saleh I. Alqasoumi , Tawfik A. Al-Howiriny and Maged S. Abdel-Kader
  In a project to search for new natural hepatroprotective agents 3 plant extracts; Aloe vera, Clematis hirsute and Cucumis prophetarum, in addition to Bee Propolis were studied. The ethanol extracts of the 3 plants and propolis were subjected to hepatoprotective assay using Wistar albino rats. Liver injury induced in rats using carbon tetrachloride. The biochemical parameters; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflection of the liver condition. Based on the good results of the biochemical parameters measurements, histopathological study was performed on the liver of rats treated with Propolis and Aloe vera. The livers of rats treated with Propolis showed good protection against the toxic effect of carbon tetrachloride. On the other hand treatment with Aloe vera extract failed to restore the normal appearance of hepatocytes. All the results were compared with silymarin, as a reference hepatoprotective drug.
  Amani S. Awaad , Shorog M. Alotiby , Reham M. El- Meligy , Mohamed S. Marzouk , Saleh I. Alqasoumi , Abd El Raheim M. Donia and Nabil H. El- Sayed
  Background and Objective: Natural products take a special interest in the discovery of new anti-ulcerogenic drugs. Family Brassicaceae is one of the most important families in use for many investigations. Cakile arabica (Velen) was used in folk medicine in treatment of gastric disorder with no scientific approve, so the aim of this study was to investigate its contents and prove their biological activities. Materials and Methods: Different chromatographic equipment and instrument were used for isolation such as column chromatography. Identification of compounds were done by several spectroscopic methods; 1H-NMR. The 13C-NMR and DEPT COSY, HSQC and HMBC. Absolute ethanol-induced ulcer model in rats were used to evaluate the anti-ulcerogenic activity using reference standard drug ranitidine (100 mg kg–1). Results: Ten compounds were isolated from C. arabica for the first time and were identified as: (1) α-amyrin, (2) β-sitosterol, (3) Tetracosanoic acid, (4) 4-hydroxy-5-n-butoxy-5-oxopentanoic acid, (5) Scopoletine, (6) Umbelliferone, (7) Esculetin, (8) Kaempferol, (9) Quercetin and (10) Quercetin-3-O-rutninoside. The total alcohol extract (1000 mg kg–1) and the isolated compounds (50 mg kg–1) showed anti-ulcerogenic activity with different potentials. The total alcohol extract was the most effective agent in this study, as it showed 98.5% protection of control ulcer followed by compounds tetracosanoic acid and 4-hydroxy-5-n-butoxy-5-oxopentanoic acid, which produced 80 and 55.5%, respectively while standard ranitidine produced 46.2%. The total alcohol extract was safe up to 4000 mg kg–1 and showed no side effects on liver and kidney functions when administrated orally for 15 consecutive days at dose 1000 mg kg–1. Conclusion: The cytoprotective mechanism may explain the potent anti-ulcerogenic activity of the Cakile arabica extract and the isolated compounds. Compounds tetracosanoic acid and 4-hydroxy-5-n-butoxy-5-oxopentanoic acid could be the main active constituents as they showed highest activities between compounds. But it is clear that there was a synergistic activity between compounds as the activity of the total extract exceeds the activity of any compound alone.
  Amani S. Awaad , Gamal A. Soliman , Dalia F. El-Sayed , Omimah D. El-Gindi and Saleh I. Alqasoumi
  Objective: The present work explored the potential hepatoprotective activity of total ethanol and successive extracts of Cyperus alternifolius L (Cyperaceae) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats and to isolate their bioactive constituents. Methods: For isolation and identification of the compounds, column chromatography and spectroscopic analysis were used, a model of hepatotoxicity by CCl4 in rats was used to evaluate the total ethanol extract and its successive fractions. Results: Phytochemical screening of C. alternifolius revealed the presence of different phytochemical groups. The plant proved to be safe for human use because it did not induce any signs of toxicity or mortality in mice when administered orally at doses up to 5000 mg kg−1. The total alcoholic extract in doses of 100 and 200 mg kg−1 and the successive extracts (ether, chloroform and ethyl acetate) in a dose of 10 mg kg−1 exhibited a significant (p ≤ 0.05) protective effect by lowering the elevated serum levels of aspartate aminotransferase: 230.4, 218.8, 224.6, 227.4 and 231.6 U L−1, respectively, compared with 111.6 U L−1 for silymarin (25 mg kg−1). Serum levels of alanine aminotransferase were also reduced: 77.4, 72.7, 79.7, 76.0 and 79.7 U L−1 compared to 63.7 U L−1 for silymarin. Alkaline phosphatase: 164.6, 158.0, 163.6, 154.7 and 166.4 U L−1 compared to 138.2 U L−1 for silymarin. Total bilirubin: 0.50, 0.46, 0.55, 0.52 and 0.57 mg dl−1 compared to 0.42 mg dl−1 for silymarin. Cholesterol: 213.1, 200.0, 192.7, 193.6 and 197.1 mg dl−1 compared to 180.3 mg dl−1 for silymarin. Triglycerides: 237.3, 222.4, 209.5, 206.8 and 210.2 mg dl−1 compared to 196.8 mg dl−1 for silymarin. Eight phenolic compounds were isolated from C. alternifolius for the first time and identified as esculetin 1, umbelliferon 2, imperatorin 3, psoralen 4, xanthotoxin 5, quercetin 6, quercetin-3-O-rutinoside 7 and gallic acid 8. Conclusions: The results concluded that C. alternifolius possesses significant protective effect against hepatotoxicity induced by CCl4.
  Saleh I. Alqasoumi , Mohammad S. Al-Dosari , Abdulmalik M. AlSheikh and Maged S. Abdel-Kader
  In a project to evaluate the efficacy of traditional Saudi plants used for liver problems the two plants Fumaria parviflora Lam. (Fumariaceae) and Momordica balsamina Linn. (Cucurbitaceae) were studied. The ethanol extract of the aerial part of Fumaria parviflora and the leaves of Momordica balsamina were subjected to hepatoprotective assays using Wistar albino rats. Liver injury induced in rats using carbon tetrachloride. The biochemical parameters; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflection of the liver condition. Based on the results of the biochemical parameters measurements, histopathological study was performed on the liver of rats treated with two extracts. The normal appearance of hepatocytes indicated a good protection of the extracts from carbon tetrachloride hepatotoxicity. All the results were compared with silymarin, the reference hepatoprotective drug.
 
 
 
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