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Articles by Sajad Hussain Mir
Total Records ( 2 ) for Sajad Hussain Mir
  Sajad Hussain Mir , M.M. Darzi , Fayaz Ahmad , M.Z. Chishti and M.S. Mir
  An experiment was conducted to study the efficacy of glimepiride (a new sulphonylurea) on the biochemical values and histomorphological features of streptozotocin-induced diabetic rabbits. Eighteen New Zealand white male rabbits were selected for the study. The rabbits were randomly divided into three Groups of six each. Group I was kept as normal healthy control (NC), Group II and Group III were made diabetic by single intravenous administration of streptozotocin (@ 65 mg/kg. b.w.). Glimepiride was given to Group III rabbits by gavage @ 2mg/kg. b.w. daily for twenty-one days whereas Group I and Group II rabbits received normal saline in the similar manner. The results indicated a significant decrease in the blood sugar (P<0.01), blood urea (P<0.001) and serum creatinine (P<0.001) in Group III rabbits. Further, the histomorphological study showed an increase in the percentage of beta cells in pancreatic islets and recovery of renal tubules in Group III rabbits. The findings indicate that glimepiride improves the biochemical values and ameliorates the histopathology of diabetic rabbits particularly restoring the morphology of beta cells of islets of Langerhan`s and thus, seems to be encouraging.
  Abdul Wahid Shah , Muni Parveen , Sajad Hussain Mir , S.G. Sarwar and A.R. Yousuf
  The present investigation carried out seasonally from March 2004 to February 2006 is an attempt to study the impact of helminth parasitism on fish haematology of Anchar Lake, Kashmir. The fish fauna viz., Schizothorax spp. and Cyprinus spp inhabiting the lake carried cestode, trematode and acanthocephala infestations either singly or mixed. The result showed a mean significant decrease from 9.39±0.18-7.39±0.14 g% in Cyprinus spp. and 10.57±0.23-7.62±0.13 g% in Schizothorax spp. for haemoglobin. Further, a decrease from 2.07±0.03-1.66±0.05 (×106 mm3) in Cyprinus spp. and 2.32±0.02-1.69±0.04 (×106 mm3) in Schizothorax spp. for RBC count in summer season was observed. However, a significant increase in WBC count was observed with a mean increase from 1.58±0.16-3.93±0.33 (×104/mm3) in Cyprinus spp. and 1.56±0.10-2.76±0.27 (×104 mm3) in Schizothorax spp. in summer season. Furthermore, a well marked increase in eosinophils was observed in all the helminth-infected fish fauna. The haematological manifestation of the infected fish are suggestive of anaemia and the eosinophilia may be believed to be associated with defensive and immunological responses of the fish.
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