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Articles by Said Hassan
Total Records ( 2 ) for Said Hassan
  Sana Ullah , Maryam Begum , Kuldeep Dhama , Saeed Ahmad , Said Hassan and Ibrar Alam
  The current study was aimed to investigate the genotoxic effect of an organophosphate pesticide malathion in the gills of a freshwater teleost rohu, Labeo rohita using alkaline Single Cell Gel Electrophoresis (SCGE)/comet assay. The 96 h LC50 of malathion was estimated for rohu in a semi-static system and was found to be 5 μg L–1. Specimens of rohu were exposed to LC50 of malathion. Gill tissues were sampled after 24, 48, 72 and 96 h of exposure. DNA damage was evaluated by studying different indices, including tail length (μm), percentage of DNA in tail, tail moment and olive tail moment using TriTek CometScoreTM. A linear relation was observed between exposure time and DNA damage in the gill cells. The current study revealed malathion as a potent inducer of DNA damage and comet assay as a reliable and sensitive assay for investigating and detecting DNA damage in vivo, induced in fish by genotoxic pesticides. In order to conserve the vanishing populations of rohu in natural aquatic bodies across the country, indiscriminate use of genotoxic pesticides such as malathion should be minimized.
  Sana Ullah , Said Hassan and Kuldeep Dhama
  The current study was designed to assess heavy metals’ concentration in muscle tissues of two Chinese carps, common carp (Cyprinus carpio) and silver carp (Hypophthalmichthys molitrix), available to consumers in markets at district Lower Dir, Khyber Pakhtunkhwa, Pakistan. Fish specimens were collected from three main markets in the study area namely; Chakdara, Timergara and Khall. Heavy metals including; manganese (Mn), lead (Pb), iron (Fe), copper (Cu), zinc (Zn), cadmium (Cd) and cobalt (Co) were investigated using atomic absorption spectrophotometer. Cobalt was not detected in any of the fish specimens while the rest of the metals were lying within the permissible limits suggested by FAO/WHO and ITS for food/fish consumption. The results showed a statistically significant (p<0.05) difference between both species with respect to the concentration of the accumulated heavy metals. In common carp, the heavy metal accumulation was in order of Fe>Mn>Zn>Pb>Cu>Cd, while in silver carp the order was Fe>Mn>Zn>Pb>Cd>Cu. Higher concentration of Pb, Mn, Zn, Cu and Cd was recorded in muscle of common carp while the concentration of Fe was higher in silver carp, indicating higher potential of accumulation of heavy metals in common carp. Statistically significant (p<0.05) correlation was observed between Pb and Zn in common carp while between Cu and Cd in silver carp. The concentration of heavy metals was in the suggested permissible limits and poses no threat if consumed. In order to maintain the heavy metals level within permissible limits, proper care should be taken along with regular assessment.
 
 
 
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