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Articles by Sahar Y. Al-Okbi
Total Records ( 2 ) for Sahar Y. Al-Okbi
  Sahar Y. Al-Okbi , Doha A. Mohamed , Thanaa E. Hamed , Ahmed M.M. Gabr , Hoda B. Mabrok , Shaimaa E. Mohammed and Oksana Sytar
  Background and Objective: Non-alcoholic fatty liver is recognized as the hepatic component of metabolic syndrome that accused for induction of cardiovascular and chronic liver diseases. This research evaluated the protective effect of two varieties of buckwheat seeds; Rubra and Karadag and their calli prepared by biotechnology towards non-alcoholic fatty liver in rat. Materials and Methods: Total phenolics, flavonoids, flavonols and DPPH free radical scavenging activity of buckwheat seeds and calli were assessed. Metabolic syndrome together with non-alcoholic fatty liver (MF) was induced by maintaining rats on high fructose diet. Daily oral dose of buckwheat seeds and calli (40 mg/rat) were given to 4 different groups during MF induction and compared to MF control rats and control group fed on balanced diet (NC). The experiment continued for 5 weeks. Results: In vitro free radical scavenging activities, total phenolic and flavonols of the calli were shown to be higher than the seeds. In vivo study showed significant dyslipidemia, significant increase in malondialdehyde, tumor necrosis factor-alpha, transaminase activity and liver fats in MF control group compared to NC. The relative gene expression of transforming growth factor beta-1 (TGF-β1) and TGF-β1 receptors I in liver as fibrogenic markers was significantly up-regulated in MF control group compared to NC. Treatment with different buckwheat forms produced improvement of the various determined plasma parameters and liver fats with variable degrees. Also, mRNA expression of TGF-β1 and TGF-β1 receptors I genes were significantly down-regulated in rats' liver on treatment with buckwheat seeds and calli. Conclusion: Buckwheat seeds and calli showed improvement of fatty liver and fibrogenic biomarkers.
  Sahar Y. Al-Okbi , Ahmed M.S. Hussein , Hagar F.H. Elbakry , Karem Aly Fouda , Khaled F. Mahmoud and Mohamed E. Hassan
  Background and Objective: Dyslipidemia is a major health problem that may lead to cardiovascular diseases (CVDs). In the present research, a biological experiment was run on dyslipidemic rats to study the health benefits of the volatile oils (VOs) of fennel and rosemary in its original and nano-form using chitosan as carrier. Materials and Methods: Rats were divided into 6 groups; normal control, dyslipidemic control and 4 test groups with dyslipidemia and treated by VOs of fennel and rosemary and their respective nano-forms separately. Glucose tolerance test was carried out after 4 weeks. Parameters reflecting oxidative stress/antioxidant plasma catalase, malondialdehyde (MDA) and blood uric acid, were assessed. Plasma lipid profile and tumor necrosis factor alpha (TNF-α) as inflammatory biomarker were determined. Liver and kidney function were assessed as determinant of the safety of the different VO forms. Twenty four hour urinary volume was measured to assess creatinine clearance and to evaluate the possible diuretic activity of the VOs. Results: Dyslipidemic control rats showed dyslipidemia, increased CVDs risk, liver dysfunction, elevated MDA and TNF-α with marked increase in blood sugar after half an hour of glucose ingestion compared to normal control. Treatment with the four VOs forms improved the majority of the biochemical parameters. Conclusion: All treatment showed cardio and hepato- protective effect and safety towards kidney and blood sugar. Oxidative stress and inflammatory biomarkers were significantly improved by the different treatments; both VO forms of fennel were more efficient in ameliorating inflammation.
 
 
 
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