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| Articles
by
Sachin Bharat Agawane |
Total Records (
1 ) for
Sachin Bharat Agawane |
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Ashok Kumar Tiwari
,
Iragavarapu Anusha
,
Maddineni Sumangali
,
Domati Anand Kumar
,
Kuncha Madhusudana
and
Sachin Bharat Agawane
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Aim: Increased consumption of sugar-sweetened beverages have been
identified as one of the major sources responsible for increasing global epidemic
of hyperglycemia, hyperglycemia induced oxidative stress and consequently, development
of number of diabetic complications. This research explored preventive and therapeutic
potentials of fruit juice of Benincasa hispida (BH) and Sechium edule
(SE) in fructose and sucrose-sweetened beverages induced Impaired Glucose Tolerance
(IGT), oxidative stress and IGT induced other metabolic disturbances in rats.
Materials and Methods: Rats were orally administered fructose and sucrose
sweetened-beverage prepared in water and respective fruit’s juice for one
month. A group of rats were maintained for three months on daily single dose
of sucrose. Three months sucrose-fed rats were later treated with fruit’s
juice for fifteen days. Degree of IGT development was determined following Oral
Glucose Tolerance Test (OGTT). Shape of plasma glucose concentration curve following
OGTT, glycemic load, plasma Total Antioxidant Potential (TAOP), oxidative stress
status, platelet aggregation activity and, Advanced Glycation End-products (AGEs)
level in blood of rats were examined. Results: Fructose was more potent
in inducing IGT than sucrose. Sucrose was more potent in decreasing plasma TAOP
and inducing oxidative stress than fructose. BH juice prevented development
of IGT induced by fructose and also significantly (p<0.05) reduced two hour
glycemic load following OGTT. Three months continuous single dose administration
of sucrose in rats induced development of IGT, increased two hour glycemic load
(p<0.05) following OGTT, decreased TAOP (p<0.05), increased oxidative
stress (more than twice) when compared with normal rats. Treatment of theses
rats with juice of BH and SE accelerated normalization of oral glucose tolerance
ability and decreased oxidative stress, platelet aggregation and accumulation
of AGEs in sucrose induced IGT and oxidatively stressed rat. Conclusion:
Our observations reveal that consumption of BH and SE juice may help reduce
development of hyperglycemia and hyperglycemia induced development of complications
by virtue of their antihyperglycemic and antioxidative stress potentials. |
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