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Articles by Sabry A. El-Naggar
Total Records ( 2 ) for Sabry A. El-Naggar
  Sabry A. EL-Naggar , Ahmed A. El-Barbary , Merveet A. Mansour , Fawzya Abdel-Shafy and Shaimaa Talat
  Recently, identifying new chemo-preventive agents to replace the current chemotherapies consider one of the most important approaches which could be crucial for cancer treatment. The present study was conducted to evaluate the anti-tumor activity of some newly synthesized heterocyclic 1,3,4-thiadiazole and 1,2,4-triazine derivatives. Different groups of mice were inoculated with Ehrlichs Ascites Carcinoma cells (EAC) intra-peritoneal (i.p.) (2x106 cells mouse-1). After one day of inculcation, mice were treated either with cisplatin (reference drug) or with twenty five different new derivatives of 1,3,4-thiadiazoles or 1,2,4-triazines. The anti-tumor activity of these derivatives against EAC-bearing mice were monitored through the changes in the total body weight, total ascetic volume, the number of live and dead tumor cells, median survival time (MST) and some biochemical parameters. The results showed that only five compounds of 1,3,4-thiadiazoles significantly inhibited the tumor progression after 14 days of the treatment. Interestingly, two of these compounds increased the life span of the tumored mice by 34 and 40% when compared with the untreated group. In contrast, all 1,2,4-triazine derivatives didn’t show any potential anti-tumor activity against EAC-model. In conclusion, screening of 1,3,4-thiadiazole derivatives showed a potential activity against EAC while, 1,2,4-triazine derivatives didn’t show any marked anti-tumor activity.
  Sabry A. El-Naggar , Ismail M. Al-Sharkawi and Gamal A. Madkour
  The most important definitive host of Schistosoma mansoni is the human, however, numerous other mammalian species were found to be infected with this parasite. Among these species, the wild rodents are the most common. In this study, the susceptibility of some wild rodents widely distributed in Egypt to S. mansoni infection was evaluated. Five wild species were tested for the susceptibility of S. mansoni infection in vitro; including Mus musculus (black mice), Acomys cahirinus (Cairo spiny mice), Rattus rattus (house rats), Rattus norvegilcus (Norway rats), Rattus norvegicus (albino rats) and Arvicanthis niloticus (Nile rats). Laboratory mice were used as a positive control. Rodents were infected individually with 150 S. mansoni cercariae by tail immersion and housed for 8 week post-infection. The results reported that the Nile rats showed the highest number of worm burden (90 worms), while the Norway rats and the laboratory rats showed the lowest numbers among the tested species. This study also showed that the Nile rats, the house rats and the Norway rats yielded high number of eggs in the liver tissues. In contrast, the Cairo spiny mice, the black mice and albino rats yielded low number of eggs in the liver tissue. As compared to the permissive host albino mice, the Nile rats, the black mice, the Cairo spiny mice and the house rats showed comparable granuloma size. In contrast, albino rats and Norway rats showed a small granuloma size. Alltogether, these data showed that S. mansoni infection to these wild rodents was species dependant.
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