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Articles by S.S. Wang
Total Records ( 2 ) for S.S. Wang
  H. Lu , S.S. Wang and B.Y. Zhao
  Locoweeds cause significant livestock poisoning and economic loss all over the world. The principal compound responsible for its toxicity is the indolizidine alkaloid swainsonine, a new potential anticancer and antiviral drug. O. glabra is a locoweed found mainly distributed throughout the inner Mongolia region of China and presents a serious hazard to the local livestock industry. The purpose of this study was to analyze the main toxic products of O. glabra first by TLC and GC-MS methods and then to evaluate its alkaloids’ toxicity in vivo. Twelve Sprague-Dawley rats were randomly divided into control group and experimental group in which the rats received 0 and 800 mg kg-1 (swainsonine content 88.64 mg) body weight day-1 of crude alkaloid extract by intragastric administration for 65 days. Results showed that a white needle crystal was isolated and purified through systematic extraction of the alkaloid by a silica gel column and gradient sublimation from O. glabra; it was identified to be swainsonine (SW) according to physicochemical properties and spectral data analyses. Pathological lesions were revealed in the brain, heart, liver and kidney of alkaloid-treated rats. We also observed diffuse vacuolation of neurons, epithelial cells of renal tubules by electron microscope. These histopathological changes demonstrated that the main toxic ingredient of O. glabra is swainsonine.
  J.J. Xu , S.S. Wang , D.D. Liu , L.Q. Cao , Y. Li and J.P. Tao
  Coccidiosis causes diarrhoea, dehydration and death in geese. Eastern China is a large goose-raising area in China but the coccidial infection status in geese in this region has not been reported as so far. To understand Coccidia species and infection rate, fecal samples were collected from 146 randomly selected clinically healthy domestic goose populations between August 2010 and July 2011. Oocysts were separated by a floatation technique using saturated saline. Coccidia species was identified by examining morphological features of the sporulated oocysts and further verified through animal regression test. The results showed that coccidian oocysts were detected in 87.67% of the goose population. Eight different species of the Eimeriidae family were identified, namely T. parvula Koltan (90.63%), E. hermani Farr (76.56%), E. stigmosa Klimes (48.44%), E. nocens Koltan (35.94%), E. fulva Farr (15.63%), E. anseris Koltan (9.38%), E. farri Hanson, Levine and Ivens (4.69%) and I. anseris Koltan (4.69%). Among them, the first three species were most prevalent. In addition, 87.50% of the farms had at least two commensal Coccidia species, indicating concurrent infection existed widely in geese. The analysis of coccidial infection with age revealed that the infection mainly occurred in geese older than 30 days and the infection rate increased with ages. In summary, the results suggest that the coccidial infection was common in domestic geese in eastern China and measures for prevention and treatment of coccidiosis were needed for this area.
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