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Articles by S.R. Mir
Total Records ( 6 ) for S.R. Mir
  P. Kumar , A. Semalty , S.R. Mir , M. Ali and S. Amin
  The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg-1), P. pinnata pods (300 mg kg-1), P. pinnata flowers (300 mg kg-1) and PP (100 mg kg-1), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
  A. Semalty , M. Semalty , P. Kumar , S.R. Mir , M. Ali and S. Amin
  Pongamia pinnata (family Papilionaceae) has been used for bronchitis, whooping cough, rheumatic joints and quench dipsia in diabetes. This study deals with the isolation of a new hypoglycemic phytoconstituent from P. pinnata pods. The hypoglycemic activity of the isolated phytoconstituent was evaluated in comparison of the methanolic extract of the pods.. Methanolic extract of P. pinnata pods was fractionated by column chromatography and the isolated compounds were identified by spectral analysis. A new compound named Pongamiaflavonylflavonol was isolated from chloroform: methanol (97:3) eluant. This new isolated compound was studied for hypoglycemic activity in streptozotocin induced diabetic rats. Methanolic extract of P. pinnata pods and pongamiaflavonylflavonol showed significant hypoglycemic activity in streptozotocin-induced hyperglycemic rats after oral administration. At the end of 6 h the new compound showed 12.15% reduction in blood glucose level in comparison of extract (11.36%) against the standard (16.93%). It can be concluded that the novel Pongamiaflavonylflavonol isolated from P. pinnata pods may be useful as oral hypoglycemic therapeutic agent. This may serve as a lead compound for development of more potent drugs for clinical use in diabetes.
  Afaq Ahmad Malik , Sanghmitra Suryapani , Javed Ahmad , Shahid Umar , M.Z. Abdin and S.R. Mir
  Artemisinin and its derivatives are potent anti-malarials and have become essential components of Artemisinin Based Combination Therapies (ACTs) for malarial treatment. Over 1 million deaths and 300-500 million cases of malaria are reported annually. Production of artemisinin is less as regards its world demand and access to ACTs is still limited in worst hit countries. Economics of artemisinin yield from A. annua crops determines the cost and availability of ACTs worldwide. Artemisinin yield from Artemisia annua depends on a number of factors including improved agricultural practices. An experiment was conducted in this regard to assess the impact of organic residues from urban areas and industries on A. annua L. Enhancement in artemisinin content, artemisinin yield, herb dry yield and plant characteristics were observed by the application of industrial wastes. Highest artemisinin content in leaf (0.53%) was found at flower initiation stage and highest artemisinin yield (29.97 kg ha-1) was obtained from sewage sludge biosolid treatment. The study reveals that organic waste amendments enhance herbage yield and artemisinin content so these, can be utilized for the commercial production of A. annua with additional benefits of mitigation of environmental pollution caused by the accretion of these large quantities.
  I. Nazish , R.A. Kaskoos , S.R. Mir , S. Amin and M. Ali
  Ruta graveolens L. belonging to family Rutaceae is commonly known as Common rue and locally as Sudab in India. It is an important medicinal plant used in capillary fragility, for eye diseases, as stimulant and emmenagogue. As the herb is used widely in the Indian traditional system, it was thought worthwhile to undertake the standardization of its aerial parts. Aerial parts consist mainly of leaves that are 3-5 inch long, flowers are tetramerous and fruits are 4-5 lobed. In the powdered form it had pungent odor and exceedingly bitter taste. Microscopical examination of powder of aerial parts showed fragments of epidermis, glandular trichomes, stone cells, lignified xylem elements and abundant calcium oxalate crystals. Successive extractive value was highest in aqueous extract (16.08% on dry weight basis). Mean ash values (%) were 8.13 (total), 2.01 (acid insoluble ash) and 1.02 (water soluble ash). Loss on drying was found to be 4.03% and pH values of aqueous extract was 6.74. Bitterness value of aerial parts was 1.28; foaming index was less than 100. Screening of all extracts indicated the presence of all phytoconstituents except saponins. TLC fingerprints of extracts of aerial parts were also developed.
  R.A. Kaskoos , S. Amin , M. Ali and S.R. Mir
  The present study was aimed to describe the fatty acid composition, stability and nutritional characteristics of fixed oil of Olea europaea drupes from Iraq, locally known as Zaytoon. The oil is commonly known as olive oil and is used throughout the world and is believed to have an important role in human health and nutrition. It is considered as one among newer source of edible oil. The oil is classified as generally regarded as safe (GRAS). The fact that there are few reports of analysis of olive oil from Iraq in comparison to other parts of the world also lured us to examine chemically. Fatty acid composition of the olive oil was determined by capillary GC-FID. Thirty fatty acids (95.88%) were identified in the oil. The major fatty acids of the oil were oleic acid (68.07±1.089%), palmitic acid (12.12±0.162%), arachidic acid (9.78±0.155%), docosahexaenoic acid DHA (2.65±0.041%) and eicosapentaenoic acid EPA (0.53±0.01). The DHA and EPA are highly valued polyunsaturated fatty acid (PUFA) and part of several health foods and nutraceuticals. Peroxidizability index calculated for the oil was 27.37% and unsaturated/saturated ratio was 3.25. High unsaturated fatty acid content signified its potential as a health promoter. Moreover, it can be expected to offer considerable resistance to oxidative rancidity during storage.
  A.A. Malik , J. Ahmad , S. Suryapani , M.Z. Abdin , S.R. Mir and Mohammed Ali
  India with its copiousness of exuberant flora is one of the richest countries as regards the genetic resources of medicinal plants and occupies unquestionably a premier position in the use of herbal drugs but in this era of high-tech wizardry, urbanization and industrialization has created needless disturbance in the vulnerably delicate ecosystems due to the accretion of large quantities of municipal wastes and industrial residues. On the other hand, continued applications of chemical fertilizers resulted in the contamination of surface and ground waters and have adversely affected the biological, physical and chemical properties of soil. It was therefore, suggested to find and evaluate methods which can help solve serious environmental and plant nutritional problems. An experiment was conducted in this regard at the research field of Jamia Hamdard, New Delhi, India to assess the impact of sewage sludge biosolid, composted sugarcane pressmud and farmyard manure on volatile oil content and composition of Artemisia annua Linn., an important aromatic-antibacterial herb. The oil is quite useful pharmaceutically and is used in perfumery, cosmetics, aromatherapy and dermatology as an antimicrobial agent having fungicidal properties. We undertook the present study with a view to maintain the ecosystems of the soil and mitigate environmental pollution. The principal findings revealed significant variations in the oil content and percentage occurrence of different constituents therefore, paving the way for enhanced production of volatiles in this industrial crop as well as emerging as an alternative control measure for mitigation of environmental pollution.
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